Three-component synthesis of substituted β-(trifluoromethyl)pyrroles via Grob cyclization of 1,1,1-trifluoro-3-nitrobut-2-ene with 1,3-dicarbonylic compounds and ammonia or primary amines

被引：14
|
作者：
Korotaev, Vladislav Yu. [1 ]
Barkov, Alexey Yu. [1 ]
Kotovich, Ivan V. [1 ]
Sosnovskikh, Vyacheslav Ya. [1 ]
机构：
[1] Ural Fed Univ, Dept Chem, Ekaterinburg 620083, Russia
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2012年 / 138卷
基金：
俄罗斯基础研究基金会;
关键词：
alpha-(Trifluoroethylidene)nitroethane; 1,3-Dicarbonyls; Primary amines; Three-component reaction; Grob cyclization; alpha-(Trifluoromethyl)pyrroles; PENTACYCLIC LAMELLARIN SKELETON; CONVENIENT SYNTHESIS; ACID-ESTERS; PYRROLES; FACILE; HETEROCYCLES; DERIVATIVES; 3-NITRO-2-(TRIFLUOROMETHYL)-2H-CHROMENES; TRIFLUOROMETHYLPYRROLES; CYCLOADDITION;
D O I：
10.1016/j.jfluchem.2012.03.012
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A variety of substituted beta-(trifluoromethyl)pyrroles were easily synthesized in good yields by a one-pot, three-component Grob cyclization of 1,1,1-trifluoro-3-nitrobut-2-ene with 1,3-dicarbonyls (ethyl acetoacetate, acetylacetone, benzoylacetone) and ammonia or primary aliphatic amines. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：42 / 47
页数：6
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