Activated double-negative T cells (CD3+CD4-CD8-HLA-DR+) define response to renal denervation for resistant hypertension

被引：8

作者：

Silva, Joana Delgado ^{[1
,2
]}

Almeida, Jani-Sofia ^{[3
,4
,5
,6
]}

Rodrigues-Santos, Paulo ^{[3
,4
,5
,6
]}

Rosa, Manuel Santos ^{[4
,5
,6
]}

Goncalves, Lino ^{[1
,2
,5
]}

机构：

[1] Univ Coimbra, Fac Med FMUC, Coimbra, Portugal

[2] Coimbras Hosp & Univ Ctr CHUC, Dept Cardiol, Coimbra, Portugal

[3] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Lab Immunol & Oncol, Coimbra, Portugal

[4] Univ Coimbra, Fac Med, Ctr Invest Environm Genet & Oncobiol CIMAGO, Coimbra, Portugal

[5] Univ Coimbra, Fac Med, Coimbra Inst Clin & Biomed Res iCBR, Coimbra, Portugal

[6] Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, Coimbra, Portugal

来源：

CLINICAL IMMUNOLOGY | 2020年 / 218卷

关键词：

Hypertension; Renal denervation; Double-negative T cells; Biomarker; Immune system; Inflammation; BLOOD-PRESSURE; SYMPATHETIC DENERVATION; IMMUNE-SYSTEM; PATHOGENESIS; IL-17; ERA;

D O I：

10.1016/j.clim.2020.108521

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Purpose: To explore the cellular immune response of patients with resistant hypertension treated with renal denervation (RDN). Methods and results: Twenty-three patients were included and blood samples were obtained in six timings, pre and post procedure. Response was evaluated at six-months and one year and was observed in 69.6% and 82.6% of patients, respectively. Absolute values of HLA-DR+ double negative (DN) T cells were significantly lower in the group of 'responders' at one year, and interaction between the timings were found in three T cell subsets (T CD4, T CD8 and naive T CD8 cells), with the 'responders' tending to present with lower absolute values and little inter-timing variation. Conclusions: 'Responders' significantly present with lower absolute values of activated DN T cells and have lower and more stable values of total T CD8+, CD4+, and naive T CD8+ cells. These cell types may be able to predict response to RDN.

引用

页数：9

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