A Nonhemolytic Group B Streptococcus Strain Exhibits Hypervirulence

被引：17

作者：

Gendrin, Claire ^{[1
,2
]}

Vornhagen, Jay ^{[1
,2
,3
]}

Armistead, Blair ^{[1
,2
,3
]}

Singh, Pallavi ^{[4
]}

Whidbey, Christopher ^{[1
,2
,3
]}

Merillat, Sean ^{[1
,2
]}

Knupp, David ^{[4
]}

Parker, Robert ^{[4
]}

Rogers, Lisa M. ^{[5
,6
]}

Quach, Phoenicia ^{[1
,2
]}

Iyer, Lakshminarayan M. ^{[7
]}

Aravind, L. ^{[7
]}

Manning, Shannon D. ^{[4
]}

Aronoff, David M. ^{[5
,6
]}

Rajagopal, Lakshmi ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[2] Seattle Childrens Res Inst, 1900,9th Ave, Seattle, WA 98101 USA

[3] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[4] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA

[5] Vanderbilt Univ, Sch Med, Dept Med, Div Infect Dis, Nashville, TN 37212 USA

[6] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37212 USA

[7] NIH, Computat Biol Branch, Natl Ctr Biotechnol Informat, Bldg 10, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 217卷 / 06期

基金：

美国国家卫生研究院;

关键词：

hemolysis; hyaluronidase; nonhemolytic; pigment; Streptococcus agalactiae; COLONIZATION; PENETRATION; EXPRESSION; VIRULENCE;

D O I：

10.1093/infdis/jix646

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Group B streptococci (GBS) are Gram-positive bacteria that are a leading cause of neonatal infections. Most invasive isolates are ss-hemolytic, and hemolytic activity is critical for GBS virulence. Although nonhemolytic GBS strains are occasionally isolated, they are often thought to be virulence attenuated. In this study, we show that a nonhemolytic GBS strain (GB37) isolated from a septic neonate exhibits hypervirulence. Substitution of tryptophan to leucine (W297L) in the sensor histidine kinase CovS results in constitutive kinase signaling, leading to decreased hemolysis and increased activity of the GBS hyaluronidase, HylB. These results describe how nonpigmented and nonhemolytic GBS strains can exhibit hypervirulence.

引用

页码：983 / 987

页数：5

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