The phomactins. A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes

被引：55
作者：
Goldring, William P. D. [1 ]
Pattenden, Gerald [1 ]
机构：
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
来源：
ACCOUNTS OF CHEMICAL RESEARCH | 2006年 / 39卷 / 05期
关键词：
D O I：
10.1021/ar050186c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A description of the structurally unusual "phomactin" family of platelet activating factor antagonists recently found in the marine fungus Phoma sp. is presented. The phomactins show an interesting structural and biosynthetic relationship with the more familiar taxane group of antitumor compounds isolated from yew trees. The Account highlights and discusses this unique relationship and also presents a cogent picture of plausible biogenetic interrelationships within the family of phomactins. Complementary synthetic endeavors with the phomactins are interwoven in the discussions, alongside contemporaneous biosynthetic studies with both the phomactins and the taxanes.
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页码：354 / 361
页数：8
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