Laxifloranone, a new phloroglucinol derivative from Marila laxiflora

被引：24
作者：
Bokesch, HR [1 ]
Groweiss, A [1 ]
McKee, TC [1 ]
Boyd, MR [1 ]
机构：
[1] NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 08期
关键词：
D O I：
10.1021/np990136e
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new polyisoprenylated phloroglucinol derivative has been isolated from the twigs of Marila laxiflora and characterized on the basis of 1D and 2D NMR spectra. Laxifloranone (1) shows moderate inhibition of the cytopathic effects of in vitro HIV infection.
引用
收藏
页码：1197 / 1199
页数：3
相关论文
共 13 条
  • [1] RESOLUTION AND DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY OF ALPHA-ARYL-SUBSTITUTED AND BETA-ARYL-SUBSTITUTED GAMMA-METHYLENEVALEROLACTONES, ALTERNATE SUBSTRATE-INHIBITORS FOR SERINE PROTEASES
    BAEK, DJ
    DANIELS, SB
    REED, PE
    KATZENELLENBOGEN, JA
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (16) : 3963 - 3972
  • [2] Acetogenic isoquinoline alkaloids. Part 123. Octadehydromichellamine, a structural analog of the anti-HIV michellamines without centrochirality
    Bringmann, G
    Wenzel, M
    Kelly, TR
    Boyd, MR
    Gulakowski, RJ
    Kaminsky, R
    [J]. TETRAHEDRON, 1999, 55 (06) : 1731 - 1740
  • [3] Cardellina JH, 1999, PR PHYT SOC, V43, P25
  • [4] Garsubellins, polyisoprenylated phloroglucinol derivatives from Garcinia subelliptica
    Fukuyama, Y
    Minami, H
    Kuwayama, A
    [J]. PHYTOCHEMISTRY, 1998, 49 (03) : 853 - 857
  • [5] HIV-inhibitory natural products.: 49.: Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii
    Fuller, RW
    Blunt, JW
    Boswell, JL
    Cardellina, JH
    Boyd, MR
    [J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01): : 130 - 132
  • [6] HIV-inhibitory natural products.: 50.: Vismiaphenones D-G, new prenylated benzophenones from Vismia cayennensis
    Fuller, RW
    Westergaard, CK
    Collins, JW
    Cardellina, JH
    Boyd, MR
    [J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01): : 67 - 69
  • [7] A SEMIAUTOMATED MULTIPARAMETER APPROACH FOR ANTI-HIV DRUG SCREENING
    GULAKOWSKI, RJ
    MCMAHON, JB
    STALEY, PG
    MORAN, RA
    BOYD, MR
    [J]. JOURNAL OF VIROLOGICAL METHODS, 1991, 33 (1-2) : 87 - 100
  • [8] HIV INHIBITORY NATURAL-PRODUCTS .8. THE GUTTIFERONES, HIV-INHIBITORY BENZOPHENONES FROM SYMPHONIA-GLOBULIFERA, GARCINIA-LIVINGSTONEI GARCINIA-OVALIFOLIA AND CLUSIA-ROSEA
    GUSTAFSON, KR
    BLUNT, JW
    MUNRO, MHG
    FULLER, RW
    MCKEE, TC
    CARDELLINA, JH
    MCMAHON, JB
    CRAGG, GM
    BOYD, MR
    [J]. TETRAHEDRON, 1992, 48 (46) : 10093 - 10102
  • [9] INOSET JR, 1998, PHARM BIOL, V36, P103
  • [10] Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms
    McKee, TC
    Bokesch, HR
    McCormick, JL
    Rashid, MA
    Spielvogel, D
    Gustafson, KR
    Alavanja, MM
    Cardellina, JH
    Boyd, MR
    [J]. JOURNAL OF NATURAL PRODUCTS, 1997, 60 (05): : 431 - 438
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