Laxifloranone, a new phloroglucinol derivative from Marila laxiflora

被引：24

作者：

Bokesch, HR ^{[1
]}

Groweiss, A ^{[1
]}

McKee, TC ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 08期

关键词：

D O I：

10.1021/np990136e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new polyisoprenylated phloroglucinol derivative has been isolated from the twigs of Marila laxiflora and characterized on the basis of 1D and 2D NMR spectra. Laxifloranone (1) shows moderate inhibition of the cytopathic effects of in vitro HIV infection.

引用

页码：1197 / 1199

页数：3

共 13 条

[1] RESOLUTION AND DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY OF ALPHA-ARYL-SUBSTITUTED AND BETA-ARYL-SUBSTITUTED GAMMA-METHYLENEVALEROLACTONES, ALTERNATE SUBSTRATE-INHIBITORS FOR SERINE PROTEASES [J].

BAEK, DJ ;

DANIELS, SB ;

REED, PE ;

KATZENELLENBOGEN, JA .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (16) :3963-3972

[2] Acetogenic isoquinoline alkaloids. Part 123. Octadehydromichellamine, a structural analog of the anti-HIV michellamines without centrochirality [J].

Bringmann, G ;

Wenzel, M ;

Kelly, TR ;

Boyd, MR ;

Gulakowski, RJ ;

Kaminsky, R .

TETRAHEDRON, 1999, 55 (06) :1731-1740

[3]

Cardellina JH, 1999, PR PHYT SOC, V43, P25

[4] Garsubellins, polyisoprenylated phloroglucinol derivatives from Garcinia subelliptica [J].

Fukuyama, Y ;

Minami, H ;

Kuwayama, A .

PHYTOCHEMISTRY, 1998, 49 (03) :853-857

[5] HIV-inhibitory natural products.: 49.: Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii [J].

Fuller, RW ;

Blunt, JW ;

Boswell, JL ;

Cardellina, JH ;

Boyd, MR .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01) :130-132

[6] HIV-inhibitory natural products.: 50.: Vismiaphenones D-G, new prenylated benzophenones from Vismia cayennensis [J].

Fuller, RW ;

Westergaard, CK ;

Collins, JW ;

Cardellina, JH ;

Boyd, MR .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01) :67-69

[7] A SEMIAUTOMATED MULTIPARAMETER APPROACH FOR ANTI-HIV DRUG SCREENING [J].

GULAKOWSKI, RJ ;

MCMAHON, JB ;

STALEY, PG ;

MORAN, RA ;

BOYD, MR .

JOURNAL OF VIROLOGICAL METHODS, 1991, 33 (1-2) :87-100

[8] HIV INHIBITORY NATURAL-PRODUCTS .8. THE GUTTIFERONES, HIV-INHIBITORY BENZOPHENONES FROM SYMPHONIA-GLOBULIFERA, GARCINIA-LIVINGSTONEI GARCINIA-OVALIFOLIA AND CLUSIA-ROSEA [J].

GUSTAFSON, KR ;

BLUNT, JW ;

MUNRO, MHG ;

FULLER, RW ;

MCKEE, TC ;

CARDELLINA, JH ;

MCMAHON, JB ;

CRAGG, GM ;

BOYD, MR .

TETRAHEDRON, 1992, 48 (46) :10093-10102

[9]

INOSET JR, 1998, PHARM BIOL, V36, P103

[10] Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms [J].

McKee, TC ;

Bokesch, HR ;

McCormick, JL ;

Rashid, MA ;

Spielvogel, D ;

Gustafson, KR ;

Alavanja, MM ;

Cardellina, JH ;

Boyd, MR .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (05) :431-438

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