Variation in the NRAMP1 gene does not affect susceptibility or protection in human brucellosis

被引：4

作者：

Bravo, MJ

Colmenero, JDD

Martín, J

Alonso, A

González, AC

机构：

[1] Carlos Haya Univ Hosp, Serv Immunol, Malaga, Spain

[2] Carlos Haya Univ Hosp, Internal Med Serv, Malaga, Spain

[3] Lopez Neyra Inst, Granada, Spain

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 01期

关键词：

human brucellosis; NRAMP1; polymorphism;

D O I：

10.1016/j.micinf.2005.06.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

\Genetic susceptibility to human brucellosis has so far been localized to variants of genes, which participate in the specific response and the innate immune response. The Nramp1 gene, which participates in the innate response, is related to susceptibility and protection in bovine brucellosis. We examined the polymorphism of the human NRAMP1 gene in 65 patients with brucellosis and 89 healthy controls and found no significant differences in the alleles studied. Thus, variants of the NRAMP1 gene do not appear to affect susceptibility or protection in human brucellosis. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：154 / 156

页数：3

共 14 条

[1] Susceptibility to leprosy is linked to the human NRAMP1 gene [J].