New cytochalasins from the fungus Xylaria hypoxylon

被引：65

作者：

Espada, A ^{[1
]}

RiveraSagredo, A ^{[1
]}

delaFuente, JM ^{[1
]}

HuesoRodriguez, JA ^{[1
]}

Elson, SW ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,CTR INVEST BASICA,TRES CANTOS 28760,SPAIN

来源：

TETRAHEDRON | 1997年 / 53卷 / 18期

关键词：

D O I：

10.1016/S0040-4020(97)00305-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six new cytochalasins together with the known compounds cytochalasins Q, 19,20-epoxy Q and R have been isolated from the fermentation broth of the fungus Xylaria hypoxylon. The structures of the new compounds were established by extensive NMR inverse spectrometry and FAB-R IS experiments. (C) 1997 Elsevier Science Ltd.

引用

页码：6485 / 6492

页数：8

共 10 条

[1] 5 10-PHENYL-[11]-CYTOCHALASANS FROM A DALDINIA FUNGAL SPECIES [J].

BUCHANAN, M ;

HASHIMOTO, T ;

ASAKAWA, Y .

PHYTOCHEMISTRY, 1995, 40 (01) :135-140

[2] EFFECTS OF CYTOCHALASINS ON MAMMALIAN CELLS [J].

CARTER, SB .

NATURE, 1967, 213 (5073) :261-&

[3] 2 NEW CYTOTOXIC CYTOCHALASINS FROM XYLARIA-OBOVATA [J].

DAGNE, E ;

GUNATILAKA, AAL ;

ASMELLASH, S ;

ABATE, D ;

KINGSTON, DGI ;

HOFMANN, GA ;

JOHNSON, RK .

TETRAHEDRON, 1994, 50 (19) :5615-5620

[4] METABOLITES OF THE HIGHER FUNGI .26. CUBENSIC ACID, 3,7,11,15-TETRAHYDROXY-18-(HYDROXYMETHYL)-2,4,6,10,14,16,20-HEPTAMETHYLDOCOSA-4E,8E,12E,16E-TETRAENOIC ACID, A NOVEL POLYSUBSTITUTED C22 FATTY-ACID FROM THE FUNGUS XYLARIA-CUBENSIS (MONT) FR WITH SUBSTITUENTS AND SUBSTITUTION PATTERN SIMILAR TO THE MACROLIDE ANTIBIOTICS [J].

EDWARDS, RL ;

MAITLAND, DJ ;

WHALLEY, AJS .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (06) :1411-&

[5] METABOLITES OF THE HIGHER FUNGI .24. CYTOCHALASIN-N, CYTOCHALASIN-O, CYTOCHALASIN-P, CYTOCHALASIN-Q, AND CYTOCHALASIN-R - NEW CYTOCHALASINS FROM THE FUNGUS HYPOXYLON-TERRICOLA MILL [J].

EDWARDS, RL ;

MAITLAND, DJ ;

WHALLEY, AJS .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (01) :57-65

[6] ANTITUMOR ACTIVITY OF CYTOCHALASIN-D [J].

KATAGIRI, K ;

MATSUURA, S .

JOURNAL OF ANTIBIOTICS, 1971, 24 (10) :722-&

[7]

MARTIN PJ, 1970, AFR BOT, V34, P303

[8] L-696,474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE .2. ISOLATION AND STRUCTURE [J].

ONDEYKA, J ;

HENSENS, OD ;

ZINK, D ;

BALL, R ;

LINGHAM, RB ;

BILLS, G ;

DOMBROWSKI, A ;

GOETZ, M .

JOURNAL OF ANTIBIOTICS, 1992, 45 (05) :679-685

[9] ENGLEROMYCIN, A NEW CYTOCHALASAN FROM ENGLEROMYCES-GOETZEI HENNINGS [J].

PEDERSEN, EJ ;

LARSEN, P ;

BOLL, PM .

TETRAHEDRON LETTERS, 1980, 21 (52) :5079-5082

[10]

TURNER WB, 1983, FUNGAL METABOLITES, V2, P461

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