The ankyrin repeat: a diversity of interactions on a common structural framework

被引：663
|
作者：
Sedgwick, SG
Smerdon, SJ
机构：
[1] Natl Inst Med Res, Div Yeast Genet, London NW7 1AA, England
[2] Natl Inst Med Res, Div Prot Struct, London NW7 1AA, England
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 08期
关键词：
D O I：
10.1016/S0968-0004(99)01426-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ankyrin repeat is one of the most common protein sequence motifs. Recent X-ray and MMR structures of ankyrin-repeat proteins and their complexes have provided invaluable insights into the molecular basis of the extraordinary variety of biological activities of these molecules. In particular, they have begun to reveal how a large family of structurally related proteins can interact specifically with such a diverse array of macromolecular targets.
引用
收藏
页码：311 / 316
页数：6
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