Clinical use of brain volumetry

被引：119
作者：
Giorgio, Antonio [1 ]
De Stefano, Nicola [1 ]
机构：
[1] Univ Siena, Dept Neurol & Behav Sci, I-53100 Siena, Italy
来源：
JOURNAL OF MAGNETIC RESONANCE IMAGING | 2013年 / 37卷 / 01期
关键词：
volumetric MRI; brain atrophy; Alzheimer's disease; multiple sclerosis; parkinsonisms; epilepsy; REMITTING MULTIPLE-SCLEROSIS; MILD COGNITIVE IMPAIRMENT; FOCAL CORTICAL DYSPLASIA; PLACEBO-CONTROLLED TRIAL; GRAY-MATTER ATROPHY; FAMILIAL ALZHEIMERS-DISEASE; TEMPORAL-LOBE EPILEPSY; FRONTOTEMPORAL DEMENTIA; HIPPOCAMPAL ATROPHY; CEREBRAL ATROPHY;
D O I：
10.1002/jmri.23671
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Magnetic resonance imaging (MRI)-based brain volumetry is increasingly being used in the clinical setting to assess brain volume changes from structural MR images in a range of neurologic conditions. Measures of brain volumes have been shown to be valid biomarkers of the clinical state and progression by offering high reliability and robust inferences on the underlying disease-related mechanisms. This review critically examines the different scenarios of the application of MRI-based brain volumetry in neurology: 1) supporting disease diagnosis, 2) understanding mechanisms and tracking clinical progression of disease, and 3) monitoring treatment effect. These aspects will be discussed in a wide range of neurologic conditions, with particular emphasis on Alzheimer's disease and multiple sclerosis. J. Magn. Reson. Imaging 2013;37:114. (c) 2012 Wiley Periodicals, Inc.
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页码：1 / +
页数：14
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