Small conjugate-based theranostic agents: an encouraging approach for cancer therapy

被引:346
作者
Kumar, Rajesh [1 ]
Shin, Weon Sup [1 ]
Sunwoo, Kyoung [1 ]
Kim, Won Young [1 ]
Koo, Seyoung [1 ]
Bhuniya, Sankarprasad [2 ,3 ]
Kim, Jong Seung [1 ]
机构
[1] Korea Univ, Dept Chem, Seoul 136701, South Korea
[2] Amrita Vishwa Vidyapeetham, Amrita Ctr Ind Res & Innovat, Coimbatore 641112, Tamil Nadu, India
[3] Amrita Vishwa Vidyapeetham, Dept Chem Engn & Mat Sci, Coimbatore 641112, Tamil Nadu, India
基金
新加坡国家研究基金会;
关键词
AGGREGATION-INDUCED-EMISSION; DRUG-DELIVERY SYSTEM; ANTICANCER AGENTS; IN-VIVO; GEMCITABINE DELIVERY; PLATINUM(IV) PRODRUG; ACTIVATABLE PRODRUG; COMBRETASTATIN A-4; COMPLEXES; MITOCHONDRIA;
D O I
10.1039/c5cs00224a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The advances in genomics, proteomics, and bioinformatics have directed the development of new anticancer agents to reduce drug abuse and increase safe and specific drug treatment. Theranostics, combining therapy and diagnosis, is an appealing approach for chemotherapy in medicine which exhibits improved biodistribution, selective cancer targeting ability, reduced toxicity, masked drug efficacy, and minimum side effects. The role of diagnosis tools in theranostics is to collect the information of the diseased state before and after specific treatment. Magnetic particle-, mesoporous silica-, various carbon allotrope-, and polymer nanoparticle-based theranostic systems are well accepted and clinically significant. Currently, small conjugate-based systems have received much attention for cancer treatment and diagnosis. The structural architecture of these systems is relatively simple, compact, biocompatible, and unidirectional. In this tutorial review, we summarize the latest developments on small conjugate based theranostic agents for tumor treatment and diagnosis using fluorescence and magnetic resonance imaging (MRI).
引用
收藏
页码:6670 / 6683
页数:14
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