Immunity and Inflammation in Atherosclerosis

被引：1495

作者：

Wolf, Dennis ^{[1
,2
]}

Ley, Klaus ^{[3
,4
]}

机构：

[1] Univ Heart Ctr Freiburg, Dept Cardiol & Angiol 1, Freiburg, Germany

[2] Univ Freiburg, Fac Med, Freiburg, Germany

[3] La Jolla Inst Immunol, Div Inflammat Biol, La Jolla, CA USA

[4] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

来源：

CIRCULATION RESEARCH | 2019年 / 124卷 / 02期

关键词：

adaptive immunity; atherosclerosis; immunity; inflammation; myeloid cells; vaccination; REGULATORY T-CELLS; LOW-DENSITY-LIPOPROTEIN; DEFICIENCY INCREASES ATHEROSCLEROSIS; OXIDATION-SPECIFIC EPITOPES; CORONARY-ARTERY-DISEASE; NATURAL-KILLER-CELLS; C-REACTIVE PROTEIN; B-CELLS; DENDRITIC CELLS; OXIDIZED LDL;

D O I：

10.1161/CIRCRESAHA.118.313591

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.

引用

页码：315 / 327

页数：13

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