Acute promyelocytic leukemic involvement of the optic nerves following mitoxantrone treatment for multiple sclerosis

被引：6

作者：

Ko, Melissa W. ^{[1
]}

Tamhankar, Madhura A. ^{[2
]}

Volpe, Nicholas J. ^{[2
]}

Porter, David ^{[3
]}

McGrath, Cindy ^{[4
]}

Galetta, Steven L. ^{[2
,5
]}

机构：

[1] SUNY Syracuse, Upstate Med Univ, Dept Neurol, Syracuse, NY USA

[2] Univ Penn, Sch Med, Dept Ophthalmol, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Hematol Oncol, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2008年 / 273卷 / 1-2期

关键词：

acute promyelocytic leukemia; optic nerve; mitoxantrone; multiple sclerosis;

D O I：

10.1016/j.jns.2008.06.028

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mitoxantrone, the first immunosuppressant to receive FDA approval for treatment of worsening relapsing-remitting, secondary progressive, and progressive-relapsing multiple sclerosis (MS) is a DNA topoisomerase II inhibitor that has been associated with the development of acute promyelocytic myelogenous leukemia (APML). Central nervous system APML is a rare site of extramedullary involvement following mitoxantrone therapy. We report a patient with history of multiple sclerosis who developed bilateral optic nerve involvementas the primary manifestation of APML relapse following mitoxantrone treatment. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：144 / 147

页数：4

共 26 条

[1] Acute myeloid leukaemia induced by mitoxantrone -: Case report [J].

Arruda, WO ;

Montú, MB ;

de Oliveira, MD ;

Ramina, R .

ARQUIVOS DE NEURO-PSIQUIATRIA, 2005, 63 (2A) :327-329

[2] Meningeal relapse in a patient with acute promyelocytic leukemia a case report and review of the literature [J].

Bae, SH ;

Ryoo, HM ;

Cho, HS ;

Lee, JL ;

Lee, KH ;

Hyun, MS .

JOURNAL OF KOREAN MEDICAL SCIENCE, 2004, 19 (02) :311-314

[3] Therapy-related acute promyelocytic leukemia [J].

Beaumont, M ;

Sanz, M ;

Carli, PM ;

Maloisel, F ;

Thomas, X ;

Detourmignies, L ;

Guerci, A ;

Gratecos, N ;

Rayon, C ;

Miguel, JS ;

Odriozola, J ;

Cahn, JY ;

Huguet, F ;

Vekhof, A ;

Stamatoulas, A ;

Dombret, H ;

Capote, F ;

Esteve, J ;

Stoppa, AM ;

Fenaux, P .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (11) :2123-2137

[4]

BROWN DM, 1992, OPHTHALMOLOGY, V99, P1463

[5] CNS relapses of acute promyelocytic leukemia after all-trans retinoic acid [J].

Burry, LD ;

Seki, JT .

ANNALS OF PHARMACOTHERAPY, 2002, 36 (12) :1900-1906

[6] HIGH PERIPHERAL BLAST COUNT IN ADULT ACUTE MYELOGENOUS LEUKEMIA IS A PRIMARY RISK FACTOR FOR CNS LEUKEMIA [J].

CASSILETH, PA ;

SYLVESTER, LS ;

BENNETT, JM ;

BEGG, CB .

JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (03) :495-498

[7] A case of acute promyelocytic leukaemia following mitoxantrone treatment of multiple sclerosis [J].

Cattaneo, C ;

Almici, C ;

Borlenghi, E ;

Motta, M ;

Rossi, G .

LEUKEMIA, 2003, 17 (05) :985-986

[8]

DEKKER AW, 1985, CANCER-AM CANCER SOC, V56, P2078, DOI 10.1002/1097-0142(19851015)56:8<2078::AID-CNCR2820560832>3.0.CO

[9]

2-0

[10] Central nervous system relapse in acute promyelocytic leukaemia in patients treated with all-trans retinoic acid [J].

Evans, G ;

Grimwade, D ;

Prentice, HG ;

Simpson, N .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 98 (02) :437-439

← 1 2 3 →