共 140 条
Crosstalk between T Lymphocytes and Dendritic Cells
被引:88
作者:
Hivroz, Claire
[1
,2
]
Chemin, Karine
[1
,2
,3
]
Tourret, Marie
[1
,2
]
Bohineust, Armelle
[1
,2
]
机构:
[1] Inst Curie, Ctr Rech, F-75248 Paris, France
[2] INSERM, Immunite & Canc U932, F-75248 Paris, France
[3] Karolinska Inst, Dept Med, Ctr Mol Med, Rheumatol Unit, SE-17176 Stockholm, Sweden
关键词:
Immunological synapse;
cytoskeleton;
dendritic cell;
T lymphocyte;
ALDRICH-SYNDROME PROTEIN;
MICROTUBULE-ORGANIZING CENTER;
COSTIMULATORY LIGAND CD70;
IMMUNOLOGICAL SYNAPSE;
IMMUNE SYNAPSE;
CUTTING EDGE;
LIPID RAFT;
LYMPH-NODES;
CYTOSKELETAL POLARIZATION;
STIMULATORY CAPACITY;
D O I:
10.1615/CritRevImmunol.v32.i2.30
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique property of inducing priming and differentiation of naive CD4(+) and CD8(+) T cells into helper and cytotoxic effectors. Their efficiency is due to their unique ability to process antigen, express costimulatory molecules, secrete cytokines, and migrate to tissues or lymphoid organs to prime T cells. DCs also play an important role in T-cell peripheral tolerance. There is ample evidence that the DC ability to present antigens is regulated by CD4(+) helper T cells. Indeed, interactions between surface receptors and ligands expressed respectively by T cells and DCs, as well as T-cell-derived cytokines modify DC functions. This T-cell induced modification of DCs has been called "education" or "licensing." This intimate crosstalk between DCs and T lymphocytes is key in establishing appropriate adaptive immune responses. It requires cognate interactions between T lymphocytes and DCs, which are organized in time and space by structures called immunological synapses. Here we discuss the particular aspects of immunological synapses formed between T cells and DCs and the role these organized interactions have in T-cell-DC crosstalk.
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页码:139 / 155
页数:17
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