Human Mesenchymal Stem Cells for Spinal Cord Injury

被引：20

作者：

Alishahi, Masoumeh ^{[1
]}

Anbiyaiee, Amir ^{[2
]}

Farzaneh, Maryam ^{[3
]}

Khoshnam, Seyed E. ^{[3
]}

机构：

[1] Islamic Azad Univ, Tehran North Branch, Dept Biol, Tehran, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Surg, Ahvaz 6135715794, Iran

[3] Ahvaz Jundishapur Univ Med Sci, Physiol Res Ctr, Ahvaz, Iran

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2020年 / 15卷 / 04期

关键词：

Spinal cord injury; cell-based therapies; stem cells; mesenchymal stem cells; devastating disease; somatic stem cells; HUMAN BONE-MARROW; FUNCTIONAL RECOVERY; STROMAL CELLS; ADIPOSE-TISSUE; IN-VITRO; TRANSPLANTATION; DIFFERENTIATION; REGENERATION; MECHANISMS; STRATEGIES;

D O I：

10.2174/1574888X15666200316164051

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Spinal Cord Injury (SCI), as a devastating and life-altering neurological disorder, is one of the most serious health issues. Currently, the management of acute SCI includes pharmacotherapy and surgical decompression. Both the approaches have been observed to have adverse physiological effects on SCI patients. Therefore, novel therapeutic targets for the management of SCI are urgently required for developing cell-based therapies. Multipotent stein cells, as a novel strategy for the treatment of tissue injury, may provide an efketive therapeutic option against many neurological disorders. Mesenchymal stem cells (MSCs) or multipotent stromal cells can typically self-renew and generate various cell types. These cells are often isolated from bone marrow (BM-MSCs), adipose tissues (AD-MSCs), umbilical cord blood (UCB-MSCs), and placenta (PMSCs). MSCs have remarkable potential for the development of regenerative therapies in animal models and humans with SCI. Herein, we summarize the therapeutic potential of human MSCs in the treatment of SCI.

引用

页码：340 / 348

页数：9

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