Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease

Background: The aim of the present study was to investigate the diagnostic value of the N-terminal B-type natriuretic peptide (NT-proBNP) in acute Kawasaki disease (KD) given that the clinical criteria and the current basic laboratory tests lack the necessary specificity for accurate diagnosis. Methods: Basic biological tests and serum NT-proBNP levels obtained from acute KD patients were compared to that of febrile controls. NT-proBNP was considered abnormal based on the following definitions: above a cut-off determined on receiver operator characteristic (ROC) analysis, above the upper limit for age, or above 2 SD calculated from healthy children. Analyses were also performed for KD cases with complete or incomplete criteria combined and separately. Results: There were 81 patients and 49 controls aged 3.60 +/- 2.77 versus 4.25 +/- 3.88 years (P= 0.69). ROC analysis yielded significant area under the curve for NT-proBNP. The sensitivity, specificity, positive and negative predictive values were 70.488.9%, 69.491.8%, 82.893.4%, and 65.279.1%. The odds ratios based on NT-proBNP definitions varied between 18.13 (95% confidence interval [CI]: 7.2145.57), 20.82 (95%CI: 8.1853.0), and 26.71 (95%CI: 8.6482.57; P < 0.001). Results were reproducible for cases with complete or incomplete criteria separately. Conclusion: NT-proBNP is a reliable marker for the diagnosis of KD. Prospective clinical studies with emphasis on NT-proBNP in a diagnostic algorithm are needed.