Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test?

被引:478
|
作者
Lammer, E. [1 ]
Carr, G. J. [2 ]
Wendler, K. [1 ]
Rawlings, J. M. [2 ]
Belanger, S. E. [2 ]
Braunbeck, Th. [1 ]
机构
[1] Univ Heidelberg, Dept Zool, Aquat Ecol & Toxicol Sect, D-69120 Heidelberg, Germany
[2] Procter & Gamble Co, Cent Product Safety Environm, Miami Valley Innovat Ctr, Cincinnati, OH 45253 USA
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 2009年 / 149卷 / 02期
关键词
Fish testing; REACH; Acute fish test alternatives; Embryo toxicity; Correlation analysis; BRACHYDANIO-RERIO; RISK-ASSESSMENT; RTG-2; CYTOTOXICITY; ORYZIAS-LATIPES; EAT DATABASE; CHEMICALS; REACH; ECOTOXICOLOGY; ASSAYS; CELLS;
D O I
10.1016/j.cbpc.2008.11.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The fish acute toxicity test is a mandatory component in the base set of data requirements for ecotoxicity testing. The fish acute toxicity test is not compatible with most current animal welfare legislation because mortality is the primary endpoint and it is often hypothesized that fish suffer distress and perhaps pain. Animal alternative considerations have also been incorporated into new European REACH regulations through strong advocacy for the reduction of testing with live animals. One of the most promising alternative approaches to classical acute fish toxicity testing with live fish is the fish embryo toxicity (FET) test. The FET has been a mandatory component in routine whole effluent testing in Germany since 2005 and has already been standardized at the international level. In order to analyze the applicability of the FET also in chemical testing, a comparative re-evaluation of both fish and fish embryo toxicity data was carried out for a total of 143 substances, and statistical approaches were developed to evaluate the correlation between fish and fish embryo toxicity data. Results confirm that fish embryo tests are neither better nor worse than acute fish toxicity tests and provide strong scientific support for the FET as a surrogate for the acute fish toxicity test. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:196 / 209
页数:14
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