Treatment of severe and uncomplicated falciparum malaria in children in France

被引：3

作者：

Pull, L. ^{[1
]}

Bellettre, X. ^{[1
]}

Michel, J. F. ^{[1
]}

Bouchaud, O. ^{[2
]}

Siriez, J. Y. ^{[1
]}

机构：

[1] Hop Robert Debre, AP HP, Serv Accueil Urgences Pediat, F-75019 Paris, France

[2] Hop Avicenne, AP HP, Serv Malad Infect & Trop, F-93000 Bobigny, France

来源：

ARCHIVES DE PEDIATRIE | 2013年 / 20卷 / 11期

关键词：

DIHYDROARTEMISININ-PIPERAQUINE; ARTEMETHER-LUMEFANTRINE; INTRAVENOUS ARTESUNATE; AFRICAN CHILDREN; EFFICACY; ATOVAQUONE; PROGUANIL; QUININE; SAFETY; HALOFANTRINE;

D O I：

10.1016/j.arcped.2013.08.002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Quinine was the main treatment for malaria between 1630 and the beginning of the XXth century. In the 1940s, the synthesis of chloroquine gave rise to the hope of eliminating this plague. Falciparum resistance to chloroquine, first observed in Asia then in sub-Saharan Africa, lead researchers to discover halofantrine, mefloquine, atovaquone-proguanil and artemisinin combined therapies. There is no ideal treatment for uncomplicated imported malaria in children. Medical teams have to develop a protocol according to available drugs and their personal experience, with a special attention to follow-up at days 3-4 and day 28. From now on, severe malaria must be treated with intravenous artesunate, a more effective therapy than quinine. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：1260 / 1264

页数：5

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