Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

被引：54

作者：

Reus, L. M. ^{[1
]}

Shen, X. ^{[1
]}

Gibson, J. ^{[1
]}

Wigmore, E. ^{[1
]}

Ligthart, L. ^{[2
]}

Adams, M. J. ^{[1
]}

Davies, G. ^{[3
]}

Cox, S. R. ^{[3
,4
]}

Hagenaars, S. P. ^{[1
,3
,4
]}

Bastin, M. E. ^{[3
]}

Deary, I. J. ^{[3
,4
]}

Whalley, H. C. ^{[1
]}

McIntosh, A. M. ^{[1
,3
]}

机构：

[1] Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland

[2] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

[3] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

[4] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

HIGH GENETIC RISK; SCHIZOPHRENIA; DEPRESSION; MICROSTRUCTURE; ETIOLOGY; DISORDER;

D O I：

10.1038/srep42140

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BP) are common, disabling and heritable psychiatric diseases with a complex overlapping polygenic architecture. Individuals with these disorders, as well as their unaffected relatives, show widespread structural differences in corticostriatal and limbic networks. Structural variation in many of these brain regions is also heritable and polygenic but whether their genetic architecture overlaps with that of major psychiatric disorders is unknown. We sought to address this issue by examining the impact of polygenic risk of MDD, SCZ, and BP on subcortical brain volumes and white matter (WM) microstructure in a large single sample of neuroimaging data; the UK Biobank Imaging study. The first release of UK Biobank imaging data comprised participants with overlapping genetic data and subcortical volumes (N = 978) and WM measures (N = 816). The calculation of polygenic risk scores was based on genome-wide association study results generated by the Psychiatric Genomics Consortium. Our findings indicated no statistically significant associations between either subcortical volumes or WM microstructure, and polygenic risk for MDD, SCZ or BP. These findings suggest that subcortical brain volumes and WM microstructure may not be closely linked to the genetic mechanisms of major psychiatric disorders.

引用

页数：8

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