Polymorphism of the growth hormone gene and its association with growth traits in Boer goat bucks

被引：62
|
作者：
Hua, G. H. [1 ]
Chen, S. L. [1 ]
Yu, J. N. [1 ]
Cai, K. L. [1 ]
Wu, C. J. [1 ]
Li, Q. L. [1 ]
Zhang, C. Y. [1 ]
Liang, A. X. [1 ]
Han, L. [1 ]
Geng, L. Y. [1 ]
Shen, Z. [2 ]
Xu, D. Q. [2 ]
Yang, L. G. [1 ]
机构：
[1] Huazhong Agr Univ, Coll Anim Sci & Technol, Educ Minist China Agr Anim Genet Breeding & Repro, Key Lab, Wuhan 430070, Hubei, Peoples R China
[2] Anim Husb Bur Hubei Prov, Wuhan 430070, Hubei, Peoples R China
来源：
MEAT SCIENCE | 2009年 / 81卷 / 02期
基金：
国家高技术研究发展计划(863计划);
关键词：
Boer goat; Growth hormone; Growth; PCR-RFLP; Polymorphism; MILK-PRODUCTION TRAITS; NUCLEOTIDE POLYMORPHISM; PROTEIN PERCENTAGE; DNA POLYMORPHISMS; RECEPTOR GENES; MAMMARY GROWTH; HOLSTEIN COWS; BODY-WEIGHT; DAIRY-COWS; CATTLE;
D O I：
10.1016/j.meatsci.2008.08.015
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
In the present study, the polymorphism of growth hormone (GH) gene was analyzed as a genetic marker candidate for growth traits in Boer goat bucks. Two single nucleotide polymorphisms (SNPs) - A781G (Ser/Gly35) and A1575C (Leu147), were identified by GH gene sequencing and PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis. AA genotype resulted in a significant decrease in birth chest girth (P = 0.03) and weaning weight (P = 0.014) comparing to AB genotype, while CC genotype contributed to weaning height (P = 0.04) greater than CD genotype. When in combination, AACD genotype was undesired for lower scores in a series of growth traits including body weight, length, height, and chest girth at birth and weaning, as well as the pre-weaning daily gain and body weight at age of 11 months. These results indicate that new molecular markers associated with caprine growth traits can be used in MAS (marker-assisted selection) in Boer goat bucks. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：391 / 395
页数：5
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