The advent of highly selective inhibitors of cyclooxygenase - A review

被引：71
作者：
Cryer, B
Dubois, A
机构：
[1] Vet Adm Med Ctr, Med Serv, Dallas, TX 75216 USA
[2] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA
[3] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Bethesda, MD 20814 USA
[4] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Surg, Bethesda, MD 20814 USA
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1998年 / 56卷 / 5-6期
关键词：
cyclooxygenase; 1; 2; gastro-intestinal tract;
D O I：
10.1016/S0090-6980(98)00064-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.
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收藏
页码：341 / 361
页数：21
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