Zr- and Hf-based nanoscale metal-organic frameworks as contrast agents for computed tomography

被引：164

作者：

deKrafft, Kathryn E. ^{[1
]}

Boyle, William S. ^{[1
]}

Burk, Laurel M. ^{[2
]}

Zhou, Otto Z. ^{[2
]}

Lin, Wenbin ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2012年 / 22卷 / 35期

关键词：

COORDINATION POLYMERS; GOLD NANOPARTICLES; FUNCTIONALIZATION; NANOMATERIALS; CRYSTALS; DESIGN; NANO;

D O I：

10.1039/c2jm32299d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Nanoscale metal-organic frameworks (NMOFs) of the UiO-66 structure containing high Zr (37 wt%) and Hf (57 wt%) content were synthesized and characterized, and their potential as contrast agents for X-ray computed tomography (CT) imaging was evaluated. Hf-NMOFs of different sizes were coated with silica and poly(ethylene glycol) (PEG) to enhance biocompatibility, and were used for in vivo CT imaging of mice, showing increased attenuation in the liver and spleen.

引用

页码：18139 / 18144

页数：6

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