Cascade Phosphinoylation/Cyclization/Isomerization Process for the Synthesis of 2-Phosphinoyl-9H-pyrrolo[1,2-a]indoles

被引：65

作者：

Chen, Su

Zhang, Pengbo

Shu, Wanyun

Gao, Yuzhen

Tang, Guo ^{[1
]}

Zhao, Yufen

机构：

[1] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 21期

关键词：

REVERSE-TRANSCRIPTASE INHIBITORS; PALLADIUM-CATALYZED PHOSPHONATION; VISIBLE-LIGHT PHOTOCATALYSIS; SECONDARY PHOSPHINE OXIDES; C-H FUNCTIONALIZATION; P BOND FORMATION; BENZOPHOSPHOLE OXIDES; ROOM-TEMPERATURE; METAL-FREE; ALKENES;

D O I：

10.1021/acs.orglett.6b02941

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrrolo[1,2-a]indole is a common structural motif found in many natural products and pharmaceuticals. A silver-mediated oxidative phosphinoylation of N-propargyl-substituted indoles was used to construct a variety of 2-phosphinoyl-9H-pyrrolo[1,2-a]indoles under mild conditions. This transformation offers a straightforward route to the formation of the CP bond, cyclization, and isomerization in one step.

引用

收藏

页码：5712 / 5715

页数：4

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