Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(p-Cymene)Cl2L] and Their Cytotoxicity against HeLa-Type Cancer Cells

被引：3
|
作者：
Fuster, Marta G. [1 ]
Moulefera, Imane [1 ]
Montalban, Mercedes G. [1 ]
Perez, Jose [2 ]
Villora, Gloria [1 ]
Garcia, Gabriel [3 ]
机构：
[1] Univ Murcia, Fac Quim, Dept Ingn Quim, Campus Reg Excelencia,Campus Mare Nostrum, E-30071 Murcia, Spain
[2] Univ Politecn Cartagena, Dept Ingn Quim & Medioambiental, ETSII, Cartagena 30203, Spain
[3] Univ Murcia, Fac Quim, Dept Quim Inorgan, Campus Reg Excelencia,Campus Mare Nostrum, E-30071 Murcia, Spain
来源：
MOLECULES | 2022年 / 27卷 / 21期
关键词：
ruthenium; complexes; cytotoxicity; anticancer activity; HeLa; MTT assay; DNA INTERACTIONS; LIGANDS; DRUGS; INHIBITION; REACTIVITY;
D O I：
10.3390/molecules27217264
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When the [Ru(p-cymene)(mu-Cl)Cl](2) complex is made to react, in dichloromethane, with the following ligands: 2-aminobenzonitrile (2abn), 4-aminobenzonitrile (4abn), 2-aminopyridine (2ampy) and 4-aminopyridine (4ampy), after addition of hexane, the following compounds are obtained: [Ru(p-cymene)Cl-2(2abn)] (I), [Ru(p-cymene)Cl-2(4abn)] (II), [Ru(p-cymene)Cl-2(2ampy] (III) and [Ru(p-cymene)Cl-2(mu-(4ampy)] (IV). All the compounds are characterized by elemental analysis of carbon, hydrogen and nitrogen, proton nuclear magnetic resonance, COSY H-1-H-1, high-resolution mass spectrometry (ESI), thermogravimetry and single-crystal X-ray diffraction (the crystal structure of III is reported and compared with the closely related literature of II). The cytotoxicity effects of complexes were described for cervical cancer HeLa cells via 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay. The results demonstrate a low in vitro anticancer potential of the complexes.
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页数：11
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