In vitro growth inhibition of human cancer cells by novel honokiol analogs

被引：40
|
作者：
Lin, Jyh Ming [1 ]
Gowda, A. S. Prakasha [1 ]
Sharma, Arun K. [2 ]
Amin, Shantu [2 ]
机构：
[1] Penn State Univ, Dept Biochem & Mol Biol, Coll Med, Hershey, PA 17033 USA
[2] Penn State Univ, Dept Pharmacol, Coll Med, Hershey, PA 17033 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 10期
关键词：
Honokiol analogs; Cell proliferation; CDK1; Cyclin B1; Human cancer cell; CYCLIN-DEPENDENT KINASES; MAGNOLIA-OFFICINALIS; LUNG-CANCER; NATURAL-PRODUCT; CYTOCHROME-C; TUMOR-CELLS; APOPTOSIS; ACTIVATION; B1; EXPRESSION;
D O I：
10.1016/j.bmc.2012.03.062
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protein levels in A549 cells. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3202 / 3211
页数：10
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