Chloriolide, a 12-membered macrolide from Chloridium wirescens var. chlamydosporum (NRRL 37636)

被引：23

作者：

Jiao, P

Swenson, DC

Gloer, JB ^{[1
]}

Wicklow, DT

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

[2] ARS, Mycotoxin Res Unit, Natl Ctr Agr Utilizat Res, USDA, Peoria, IL 61604 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np0504964

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new 12-membered macrolide (chloriolide; 1) was obtained from solid-substrate fermentation cultures of Chloridium Virescens var. chlamydosporum that was originally isolated from decayed wood. The structure of 1 was determined by analysis of 1D NMR, 2D NMR, and MS data and confirmed by X-ray crystallographic analysis. The absolute configuration of 1 was assigned by application of the modified Mosher method using the (R)- and (S)- MTPA derivatives of a rearrangement product obtained under standard acylation conditions. The assignment made by analysis of the corresponding Delta delta values was verified by X-ray crystallographic analysis of the (S)-MTPA derivative.

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页码：636 / 639

页数：4

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