Palladium catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

被引：57

作者：

Faulkner, Adele ^{[1
]}

Scott, James S. ^{[2
]}

Bower, John F. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 15期

基金：

英国工程与自然科学研究理事会;

关键词：

KETONE O-PENTAFLUOROBENZOYLOXIMES; HECK REACTIONS; ENANTIOSELECTIVE SYNTHESIS; AMMONIUM-SALTS; DERIVATIVES; REARRANGEMENT; INSERTION; ALKYNES; PHOSPHORAMIDITES; STEREOCENTERS;

D O I：

10.1039/c2cc38944d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report efficient Pd-catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes as the basis of a general entry to alpha,alpha-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.

引用

页码：1521 / 1523

页数：3

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