Complex sequence dependence by excess-electron transfer through DNA with different strength electron acceptors

被引：55
作者：
Manetto, A
Breeger, S
Chatgilialoglu, C
Carell, T
机构：
[1] Ludwig Maximilians Univ Munchen, Dept Chem & Biochem, D-81377 Munich, Germany
[2] CNR, ISOF, I-40129 Bologna, Italy
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 02期
关键词：
DNA damage; electron transfer; nucleobases; redox potential;
D O I：
10.1002/anie.200502551
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An independent jump: Excess electrons move through DNA by using a hopping-type mechanism in which the pyrimidine bases dT and dC act as 'stepping stones'. It was shown that GC base pairs, in contrast to AT base pairs, lower the efficiency of the excess-electron transfer through the duplex. Through the use of the shown DNA hairpins, three different electron acceptors (■) were investigated with the electron donor, reduced flavin (■). (Figure Presented) © 2006 Wiley-VCH Verlag GmbH &, Co. KGaA.
引用
收藏
页码：318 / 321
页数：4
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