Structured surveillance of Achromobacter, Pandoraea and Ralstonia species from patients in England with cystic fibrosis

被引：17

作者：

Coward, Amy ^{[1
,15
]}

Kenna, Dervla T. D. ^{[1
]}

Woodford, Neil ^{[1
]}

Turton, Jane F. ^{[1
]}

Armstrong, Malcolm ^{[2
]}

Auckland, Cressida ^{[3
]}

Bowler, Ian ^{[4
]}

Burns, Phillipa ^{[2
]}

Cargill, James ^{[5
]}

Carroll, Mary ^{[6
]}

Flight, William ^{[4
]}

Graver, Michelle ^{[7
]}

Green, Heather ^{[8
]}

Horner, Carolyne ^{[9
]}

Jones, Andrew ^{[10
]}

Jones, Andrew M. ^{[8
]}

Jones, Graeme ^{[6
]}

Mayell, Sarah ^{[5
]}

Orendi, Jeorge ^{[11
]}

Perry, Audrey ^{[12
]}

Robb, Ali ^{[12
]}

Tucker, Natasha ^{[6
]}

Waine, David ^{[13
]}

Winstanley, Trevor ^{[14
]}

Withers, Nick ^{[3
]}

机构：

[1] Publ Hlth England, Antimicrobial Resistance & Healthcare Associated, Natl Infect Serv, London, England

[2] Manchester Univ NHS Fdn Trust, Royal Manchester Childrens Hosp, Dept Microbiol, Manchester, Lancs, England

[3] Royal Devon & Exeter Hosp, Microbiol Dept, Exeter, Devon, England

[4] John Radcliffe Hosp, Microbiol Dept, Oxford, England

[5] Alder Hey Childrens NHS Fdn Trust, Microbiol Dept, Liverpool, Merseyside, England

[6] Univ Hosp Southampton NHS Fdn Trust, Cyst Fibrosis Unit, Southampton, Hants, England

[7] Kings Coll Hosp NHS Fdn Trust, Dept Microbiol, London, England

[8] Manchester Univ Hosp NHS Fdn Trust, Wythenshawe Hosp, Manchester Adult Cyst Fibrosis Ctr, Manchester, Lancs, England

[9] Leeds Teaching Hosp NHS Trust, Leeds Gen Infirm, Dept Microbiol, Leeds, W Yorkshire, England

[10] Royal Brompton & Harefield NHS Fdn Trust, Resp Med, London, England

[11] Royal Stoke Univ Hosp, Univ Hosp North Midlands NHS Trust, Stoke On Trent, Staffs, England

[12] Freeman Rd Hosp, Microbiol Dept, Newcastle Upon Tyne, Tyne & Wear, England

[13] Plymouth Hosp NHS Trust, Plymouth, Devon, England

[14] Sheffield Teaching Hosp NHS Fdn Trust, Northern Gen Hosp, Sheffield, S Yorkshire, England

[15] Broomfield Hosp, Chelmsford CM1 7ET, Essex, England

来源：

JOURNAL OF CYSTIC FIBROSIS | 2020年 / 19卷 / 03期

关键词：

Survey; Achromobacter; Pandoraea; Ralstonia; CF; EPIDEMIC SPREAD; PREVALENCE; INFECTION; OUTCOMES; NOV;

D O I：

10.1016/j.jcf.2019.11.005

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

A structured survey of the cystic fibrosis pathogens Achromobacter, Pandoraea and Ralstonia species from thirteen sentinel hospitals throughout England was undertaken by Public Health England. One isolate per patient of these genera collected from CF patients during the seven-month survey period in 2015 was requested from participating hospitals. Species-level identification was performed using nrdA/gyrB sequence cluster analysis, and genotyping by pulsed-field gel electrophoresis. In total, 176 isolates were included in the survey; 138 Achromobacter spp. (78.4%), 29 Pandoraea spp. (16.5%) and 9 Ralstonia spp. (5.1%). Novel Achromobacter and Pandoraea clusters were identified. High levels of antimicrobial resistance were found, particularly among Pandoraea isolates. Genotyping analysis revealed considerable diversity, however one geographically-widespread cluster of A. xylosoxidans isolates from six hospitals was found, in addition to two other clusters, both comprising isolates from two hospitals, either derived from the same region (A. xylosoxidans), or from hospitals within the same city (P. apista). Crown Copyright (C) 2019 Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society. All rights reserved.

引用

页码：388 / 393

页数：6

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