A gut-heart connection in cardiometabolic regulation

被引:22
作者
Buglioni, Alessia [1 ]
Burnett, John C., Jr. [1 ]
机构
[1] Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Cardiorenal Res Lab, Rochester, MN 55905 USA
关键词
ATRIAL-NATRIURETIC-PEPTIDE; HUMAN ADIPOCYTES; BLOOD-PRESSURE;
D O I
10.1038/nm.3196
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new study establishes a link between glucagon-like peptide-1 (GLP-1) release from the gut and the cardiac hormone atrial natriuretic peptide, which lowers blood pressure. As GLP-1 receptor agonists are used to control glycemia in patients with type 2 diabetes, this new gut-heart axis suggests a role of these agents in overall cardiovascular homeostasis (pages 567–575).
引用
收藏
页码:534 / 536
页数:3
相关论文
共 12 条
  • [1] Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
    Bordicchia, Marica
    Liu, Dianxin
    Amri, Ez-Zoubir
    Ailhaud, Gerard
    Dessi-Fulgheri, Paolo
    Zhang, Chaoying
    Takahashi, Nobuyuki
    Sarzani, Riccardo
    Collins, Sheila
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (03) : 1022 - 1036
  • [2] Cannon WB., 1932, The Wisdom of the Body
  • [3] A Genetic Variant of the Atrial Natriuretic Peptide Gene Is Associated With Cardiometabolic Protection in the General Community
    Cannone, Valentina
    Boerrigter, Guido
    Cataliotti, Alessandro
    Costello-Boerrigter, Lisa C.
    Olson, Timothy M.
    McKie, Paul M.
    Heublein, Denise M.
    Lahr, Brian D.
    Bailey, Kent R.
    Averna, Maurizio
    Redfield, Margaret M.
    Rodeheffer, Richard J.
    Burnett, John C., Jr.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (06) : 629 - 636
  • [4] Sustained Blood Pressure-Lowering Actions of Subcutaneous B-Type Natriuretic Peptide (Nesiritide) in a Patient With Uncontrolled Hypertension
    Cataliotti, Alessandro
    Costello-Boerrigter, Lisa C.
    Chen, Horng H.
    Textor, Stephen C.
    Burnett, John C., Jr.
    [J]. MAYO CLINIC PROCEEDINGS, 2012, 87 (04) : 413 - 415
  • [5] A RAPID AND POTENT NATRIURETIC RESPONSE TO INTRAVENOUS-INJECTION OF ATRIAL MYOCARDIAL EXTRACT IN RATS
    DEBOLD, AJ
    BORENSTEIN, HB
    VERESS, AT
    SONNENBERG, H
    [J]. LIFE SCIENCES, 1981, 28 (01) : 89 - 94
  • [6] Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors - The framingham offspring study
    Ingelsson, Erik
    Pencina, Michael J.
    Tofler, Geoffrey H.
    Benjamin, Emelia J.
    Lanier, Katherine J.
    Jacques, Paul F.
    Fox, Caroline S.
    Meigs, James B.
    Levy, Daniel
    Larson, Martin G.
    Selhub, Jacob
    D'Agostino, Ralph B., Sr.
    Wang, Thomas J.
    Vasan, Ramachandran S.
    [J]. CIRCULATION, 2007, 116 (09) : 984 - 992
  • [7] Physiological effects of vasopressin and atrial natriuretic peptide in the collecting duct
    Inoue, T
    Nonoguchi, H
    Tomita, K
    [J]. CARDIOVASCULAR RESEARCH, 2001, 51 (03) : 470 - 480
  • [8] GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    Kim, Minsuk
    Platt, Mathew J.
    Shibasaki, Tadao
    Quaggin, Susan E.
    Backx, Peter H.
    Seino, Susumu
    Simpson, Jeremy A.
    Drucker, Daniel J.
    [J]. NATURE MEDICINE, 2013, 19 (05) : 567 - 575
  • [9] Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Newton-Cheh, Christopher
    Larson, Martin G.
    Vasan, Ramachandran S.
    Levy, Daniel
    Bloch, Kenneth D.
    Surti, Aarti
    Guiducci, Candace
    Kathiresan, Sekar
    Benjamin, Emelia J.
    Struck, Joachim
    Morgenthaler, Nils G.
    Bergmann, Andreas
    Blankenberg, Stefan
    Kee, Frank
    Nilsson, Peter
    Yin, Xiaoyan
    Peltonen, Leena
    Vartiainen, Erkki
    Salomaa, Veikko
    Hirschhorn, Joel N.
    Melander, Olle
    Wang, Thomas J.
    [J]. NATURE GENETICS, 2009, 41 (03) : 348 - 353
  • [10] Natriuretic peptides:: a new lipolytic pathway in human adipocytes
    Sengenès, C
    Berlan, M
    De Glisezinski, I
    Lafontan, M
    Galitzky, J
    [J]. FASEB JOURNAL, 2000, 14 (10) : 1345 - 1351