A comprehensive summary of LL-37, the factotum human cathelicidin peptide

被引：460

作者：

Vandamme, Dieter ^{[1
]}

Landuyt, Bart ^{[1
]}

Luyten, Walter ^{[2
]}

Schoofs, Liliane ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Biol, Div Neurobiol & Anim Physiol, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, B-3000 Louvain, Belgium

来源：

CELLULAR IMMUNOLOGY | 2012年 / 280卷 / 01期

关键词：

Cathelicidin; Antimicrobial peptide; LL-37; Innate immunity; HUMAN ANTIMICROBIAL PEPTIDE; LIPOPOLYSACCHARIDE-BINDING-PROTEIN; POTENTIAL THERAPEUTIC APPLICATIONS; INVASIVE BACTERIAL-INFECTION; HUMAN GINGIVAL FIBROBLASTS; GROWTH-FACTOR RECEPTOR; HUMAN DENDRITIC CELLS; VITAMIN-D-RECEPTOR; EPITHELIAL-CELLS; HUMAN-NEUTROPHILS;

D O I：

10.1016/j.cellimm.2012.11.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become clear that they are an exceptional class of peptides, with some members having pleiotropic effects. Not only do they possess an antibacterial, antifungal and antiviral function, they also show a chemotactic and immunostimulatory/-modulatory effect. Moreover, they are capable of inducing wound healing, angiogenesis and modulating apoptosis. Recent insights even indicate for a role of these peptides in cancer. This review provides a comprehensive summary of the most recent and relevant insights concerning the human cathelicidin LL-37. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：22 / 35

页数：14

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