Reaction between 7,8-dihydropterins and hydrogen peroxide under physiological conditions

被引：13

作者：

Dantola, M. Laura ^{[1
]}

Schuler, Tobias M. ^{[1
]}

Denofrio, M. Paula ^{[1
]}

Vignoni, Mariana ^{[1
]}

Capparelli, Alberto L. ^{[1
]}

Lorente, Carolina ^{[1
]}

Thomas, Andres H. ^{[1
]}

机构：

[1] Univ Nacl La Plata, Fac Ciencias Exactas, Dept Quim, CONICET,INIFTA, RA-1900 La Plata, Argentina

来源：

TETRAHEDRON | 2008年 / 64卷 / 37期

关键词：

reactivity; kinetics; pterins; hydrogen peroxide;

D O I：

10.1016/j.tet.2008.07.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In vitiligo, a common skin disorder that produces white patches of depigmentation, 7,8-dihydropterins accumulate in the presence of high concentration of H2O2. In this work, we present a study of the reaction between 7,8-dihydropterins and H2O2. The rate of the reaction, as well as the products formed, strongly depend on the chemical structure of the substituents. Electron-donor groups as substituents are the most reactive derivatives and undergo oxidation of the pterin moiety. The corresponding bimolecular rate constants at 37 degrees C in neutral aqueous solutions are reported. The biological implications of the results obtained are also discussed. (c) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：8692 / 8699

页数：8

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