The role of iron metabolism in chronic diseases related to obesity

被引：21
作者：
Qiu, Fangyi [1 ]
Wu, Lei [1 ]
Yang, Guang [2 ]
Zhang, Cong [2 ]
Liu, Xiaofang [2 ]
Sun, Xiance [3 ]
Chen, Xin [4 ]
Wang, Ningning [2 ]
机构：
[1] Dalian Med Univ, Sch Publ Hlth, Dalian, Liaoning, Peoples R China
[2] Dalian Med Univ, Global Hlth Res Ctr, Sch Publ Hlth, Dept Nutr & Food Hyg, Dalian, Liaoning, Peoples R China
[3] Dalian Med Univ, Global Hlth Res Ctr, Sch Publ Hlth, Occupat & Environm Hlth Dept, Dalian, Peoples R China
[4] Dalian Med Univ, Sch Publ Hlth, Dept Epidemiol, Dalian, Liaoning, Peoples R China
来源：
MOLECULAR MEDICINE | 2022年 / 28卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Iron metabolism; Obesity; Chronic diseases; Ferroptosis; HEPATIC HEPCIDIN EXPRESSION; ISLET AMYLOID POLYPEPTIDE; DIABETES-MELLITUS; OVERLOAD SYNDROME; ADIPOSE-TISSUE; SERUM HEPCIDIN; MOUSE MODEL; DEFICIENCY; RISK; DYSFUNCTION;
D O I：
10.1186/s10020-022-00558-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Obesity is one of the major public health problems threatening the world, as well as a potential risk factor for chronic metabolic diseases. There is growing evidence that iron metabolism is altered in obese people, however, the highly refined regulation of iron metabolism in obesity and obesity-related complications is still being investigated. Iron accumulation can affect the body's sensitivity to insulin, Type 2 diabetes, liver disease and cardiovascular disease. This review summarized the changes and potential mechanisms of iron metabolism in several chronic diseases related to obesity, providing new clues for future research.
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页数：14
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