6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

被引:19
作者
Miao, Yong [1 ]
Sun, Yabin [2 ]
Wang, Wenjun [3 ]
Du, Benjun [1 ]
Xiao, Shun-e [1 ]
Hu, Yijue [1 ]
Hu, Zhiqi [1 ]
机构
[1] So Med Univ, Nanfang Hosp, Dept Plast & Aesthet Surg, Guangzhou, Guangdong, Peoples R China
[2] So Med Univ, Nanfang Hosp, GCP Off, Guangzhou, Guangdong, Peoples R China
[3] So Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R China
来源
PLOS ONE | 2013年 / 8卷 / 02期
关键词
DERMAL PAPILLA CELLS; IN-VITRO; APOPTOSIS; BCL-2; PROLIFERATION; MITOCHONDRIA; PROTEINS; ALOPECIA; SURVIVAL; EXTRACT;
D O I
10.1371/journal.pone.0057226
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ginger (Zingiber officinale) has been traditionally used to check hair loss and stimulate hair growth in East Asia. Several companies produce shampoo containing an extract of ginger claimed to have anti-hair loss and hair growth promotion properties. However, there is no scientific evidence to back up these claims. This study was undertaken to measure 6-gingerol, the main active component of ginger, on hair shaft elongation in vitro and hair growth in vivo, and to investigate its effect on human dermal papilla cells (DPCs) in vivo and in vitro. 6-Gingerol suppressed hair growth in hair follicles in culture and the proliferation of cultured DPCs. The growth inhibition of DPCs by 6-gingerol in vitro may reflect a decrease in the Bcl-2/Bax ratio. Similar results were obtained in vivo. The results of this study showed that 6-gingerol does not have the ability to promote hair growth, on the contrary, can suppress human hair growth via its inhibitory and pro-apoptotic effects on DPCs in vitro, and can cause prolongation of telogen phase in vivo. Thus, 6-gingerol rather than being a hair growth stimulating drug, it is a potential hair growth suppressive drug; i.e. for hair removal.
引用
收藏
页数:6
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