[Ru(phgly)2(binap)]/Li2CO3:: A highly active, robust, and enantioselective catalyst for the cyanosilylation of aldehydes

被引：87

作者：

Kurono, Nobuhito ^{[1
]}

Arai, Kenta ^{[1
]}

Uemura, Masato ^{[1
]}

Ohkuma, Takeshi ^{[1
]}

机构：

[1] Hokkaido Univ, Div Chem Proc Engn, Grad Sch Engn, Sapporo, Hokkaido 0608628, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 35期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

aldehydes; asymmetric catalysis; cyanosilylation; lithium; ruthenium;

D O I：

10.1002/anie.200801501

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The right combination: A series of aromatic, heteroaromatic, aliphatic, and α,β-unsaturated aldehydes can be converted into the desired silylated cyanohydrins by reaction with (CH3)3SiCN and a catalyst system consisting of the combination of a chiral ruthenium complex and Li2CO3 (see scheme). The reaction is highly enantioselective and affords the R products with up to 98% ee within 24 h at a substrate-tocatalyst ratio of 10000:1. (Chemical Equation Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6643 / 6646

页数：4

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