Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure

被引：7

作者：

Fan, Li-hong ^{[1
]}

Tian, Hong-yan ^{[1
]}

Ma, Ai-qun ^{[1
]}

Hu, Zhi ^{[1
]}

Huo, Jian-hua ^{[1
]}

Cao, Yong-xiao ^{[2
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Sch Med, Dept Cardiol, Xian 710061, Peoples R China

[2] Xi An Jiao Tong Univ, Dept Pharmacol, Sch Med, Xian 710061, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2008年 / 29卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ATP-sensitive potassium channel; obesity-hypertension; electrophysiology; aorta; mesenteric artery;

D O I：

10.1111/j.1745-7254.2008.00810.x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aim: To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. Methods: Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, K-ATP channel-mediated relaxation responses in the aortas and mesenteric arteries, K-ATP channel current, and gene expression were examined, respectively. Results: Blood pressure and body weight were increased in rats fed with high-fat diet. K-ATP channel-mediated relaxation responses, currents, and K-ATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. Conclusion: Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure.

引用

页码：1167 / 1174

页数：8

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