The genome sequencer FLX™ system-longer reads, more applications, straight forward bioinformatics and more complete data sets

被引：170

作者：

Droege, Marcus ^{[1
]}

Hill, Brendon ^{[2
]}

机构：

[1] Roche Appl Sci, Global Mkt, D-82372 Penzberg, Germany

[2] 454 Life Sci, Branford, CT USA

来源：

JOURNAL OF BIOTECHNOLOGY | 2008年 / 136卷 / 1-2期

关键词：

2nd generation sequencing technology; human re-sequencing; de novo sequencing; transcriptome analysis; microbial genome sequencing; metagenomics; plants sequencing; viral variants;

D O I：

10.1016/j.jbiotec.2008.03.021

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Genome Sequencer FLX System (GS FLX), powered by 454 Sequencing, is a next-generation DNA sequencing technology featuring a unique mix of long reads, exceptional accuracy, and ultra-high throughput. It has been proven to be the most versatile of all currently available next-generation sequencing technologies, supporting many high-profile studies in over seven applications categories. GS FLX users have pursued innovative research in de novo sequencing, re-sequencing of whole genomes and target DNA regions, metagenomics, and RNA analysis. 454 Sequencing is a powerful too] for human genetics research, having recently re-sequenced the genome of an individual human, currently re-sequencing the complete human exome and targeted genomic regions using the NimbleGen sequence capture process, nd detected low-frequency somatic mutations linked to cancer. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：3 / 10

页数：8

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