HCN Channels and Heart Rate

被引：41

作者：

Scicchitano, Pietro ^{[1
]}

Carbonara, Santa ^{[1
]}

Ricci, Gabriella ^{[1
]}

Mandurino, Cosimo ^{[1
]}

Locorotondo, Manuela ^{[1
]}

Bulzis, Gabriella ^{[1
]}

Gesualdo, Michele ^{[1
]}

Zito, Annapaola ^{[1
]}

Carbonara, Rosa ^{[1
]}

Dentamaro, Ilaria ^{[1
]}

Riccioni, Graziano ^{[2
]}

Ciccone, Marco Matteo ^{[1
]}

机构：

[1] Univ Bari, Sect Cardiovasc Dis, Dept Emergency & Organ Transplantat, Sch Med, I-70124 Bari, Italy

[2] San Camillo De Lellis Hosp, Cardiol Unit, I-71043 Manfredonia, FG, Italy

来源：

MOLECULES | 2012年 / 17卷 / 04期

关键词：

HCN channels; I-f-current; heart rate control; ivabradine; CURRENT I-F; SYSTOLIC DYSFUNCTION BEAUTIFUL; CORONARY-ARTERY-DISEASE; ACTIVATED CURRENT IF; PACE-MAKER CURRENT; PACEMAKER CHANNELS; RATE REDUCTION; ACTION-POTENTIALS; HYPERPOLARIZATION; IVABRADINE;

D O I：

10.3390/molecules17044225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hyperpolarization and Cyclic Nucleotide (HCN) -gated channels represent the molecular correlates of the "funny" pacemaker current (I-f), a current activated by hyperpolarization and considered able to influence the sinus node function in generating cardiac impulses. HCN channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. This channel family comprises four members: HCN1-4, but there is a general agreement to consider HCN4 as the main isoform able to control heart rate. This review aims to summarize advanced insights into the structure, function and cellular regulation of HCN channels in order to better understand the role of such channels in regulating heart rate and heart function in normal and pathological conditions. Therefore, we evaluated the possible therapeutic application of the selective HCN channels blockers in heart rate control.

引用

页码：4225 / 4235

页数：11

共 56 条

[1] Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node [J].