Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal

被引：322

作者：

Huang, Xi ^{[1
]}

机构：

[1] NYU, Dept Environm Med, Inst Canc, Sch Med, New York, NY 10016 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2003年 / 533卷 / 1-2期

关键词：

Iron; Cancer; Oxidative damage; Tumor suppressor genes; Hemochromatosis;

D O I：

10.1016/j.mrfmmm.2003.08.023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Unlike arsenic, chromium, or nickel, the carcinogenicity of iron is still under debate. In this review, evidence for iron as a carcinogenic metal was summarized from epidemiological, animal, and cell culture studies. The role of iron in various cancers, such as colorectal cancer and liver cancer was presented. Recent advancements on the molecular mechanisms of iron carcinogenesis were also reviewed. These include: (1) iron autoxidation involving only Fe2+ + O-2 in oxidant formation in biological systems and its pH dependency; (2) activation of oxidative responsive transcription factors and pro-inflammatory cytokines; and (3) iron-induced hypoxia signaling. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：153 / 171

页数：19

共 232 条

[11]

Bacon Bruce R., 1999, Gastroenterology, V116, P193, DOI 10.1016/S0016-5085(99)70244-1

[12] Experimental hemochromatosis due to MHC class IHFE deficiency:: Immune status and iron metabolism [J].

Bahram, S ;

Gilfillan, S ;

Kühn, LC ;

Moret, R ;

Schulze, JB ;

Lebeau, A ;

Schümann, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) :13312-13317

[13] A NEW ROLE FOR THE TRANSFERRIN RECEPTOR IN THE RELEASE OF IRON FROM TRANSFERRIN [J].

BALI, PK ;

ZAK, O ;

AISEN, P .

BIOCHEMISTRY, 1991, 30 (02) :324-328

[14]

BALLA G, 1992, J BIOL CHEM, V267, P18148

[15] VALUE OF HEPATIC IRON MEASUREMENTS IN EARLY HEMOCHROMATOSIS AND DETERMINATION OF THE CRITICAL IRON LEVEL ASSOCIATED WITH FIBROSIS [J].

BASSETT, ML ;

HALLIDAY, JW ;

POWELL, LW .

HEPATOLOGY, 1986, 6 (01) :24-29

[16] Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis [J].

Bastin, JM ;

Jones, M ;

O'Callaghan, CA ;

Schimanski, L ;

Mason, DY ;

Townsend, ARM .

BRITISH JOURNAL OF HAEMATOLOGY, 1998, 103 (04) :931-941

[17] Interaction between haemochromatosis and transferrin receptor genes in different neoplastic disorders [J].

Beckman, LE ;

Van Landeghem, GF ;

Sikström, C ;

Wahlin, A ;

Markevärn, B ;

Hallmans, G ;

Lenner, P ;

Athlin, L ;

Stenling, R ;

Beckman, L .

CARCINOGENESIS, 1999, 20 (07) :1231-1233

[18]

Beutler Ernest, 1996, Blood Cells Molecules and Diseases, V22, P187, DOI 10.1006/bcmd.1996.0027

[19] Progressive iron overload enhances chemically mediated tumor promotion in murine skin [J].

Bhasin, G ;

Kausar, H ;

Alam, MS ;

Athar, M .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2003, 409 (02) :262-273

[20] Low iron state is associated with reduced tumor promotion in a two-stage mouse skin carcinogenesis model [J].

Bhasin, G ;

Kauser, H ;

Athar, M .

FOOD AND CHEMICAL TOXICOLOGY, 2002, 40 (08) :1105-1111

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