Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal

被引：322

作者：

Huang, Xi ^{[1
]}

机构：

[1] NYU, Dept Environm Med, Inst Canc, Sch Med, New York, NY 10016 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2003年 / 533卷 / 1-2期

关键词：

Iron; Cancer; Oxidative damage; Tumor suppressor genes; Hemochromatosis;

D O I：

10.1016/j.mrfmmm.2003.08.023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Unlike arsenic, chromium, or nickel, the carcinogenicity of iron is still under debate. In this review, evidence for iron as a carcinogenic metal was summarized from epidemiological, animal, and cell culture studies. The role of iron in various cancers, such as colorectal cancer and liver cancer was presented. Recent advancements on the molecular mechanisms of iron carcinogenesis were also reviewed. These include: (1) iron autoxidation involving only Fe2+ + O-2 in oxidant formation in biological systems and its pH dependency; (2) activation of oxidative responsive transcription factors and pro-inflammatory cytokines; and (3) iron-induced hypoxia signaling. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：153 / 171

页数：19

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