Lymph node ratio predicts prognosis in patients with surgically resected invasive pancreatic cystic neoplasms

被引:4
作者
Jin, Can [1 ]
Li, Juan [2 ]
Zou, Chuanxin [1 ]
Qiao, Xu [3 ]
Ma, Peng [1 ]
Hu, Di [1 ]
Li, Wenqin [1 ]
Jin, Jun [4 ]
Meng, Zibo [5 ]
Liu, Zhiqiang [5 ]
机构
[1] Yangtze Univ, Jingzhou Cent Hosp, Clin Med Coll 2, Dept Gastroenterol, Jingzhou, Peoples R China
[2] Yangtze Univ, Jingzhou Cent Hosp, Clin Med Coll 2, Dept Gen Med, Jingzhou, Peoples R China
[3] Yangtze Univ, Jingzhou Cent Hosp, Clin Med Coll 2, Digest Endoscopy Ctr, Jingzhou, Peoples R China
[4] 909 Hosp Joint Logist Support Force PLA, Dept Oncol, Zhangzhou, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pancreat Surg, Union Hosp, Wuhan, Peoples R China
关键词
Pancreatic cystic neoplasms (PCNs); Lymph node ratio (LNR); SEER database; PAPILLARY MUCINOUS NEOPLASM; ADJUVANT RADIOTHERAPY; CANCER SURVIVAL; ADENOCARCINOMA; RECURRENCE; EPIDEMIOLOGY; SURVEILLANCE; EXPERIENCE; TUMORS;
D O I
10.21037/tcr-20-1355
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: In current days, the prevalence of pancreatic cystic neoplasms (PCN) is on the rise. Lymph node ratio (LNR) has emerged as a promising prognostic factor in pancreatic adenocarcinoma (PDAC). However, the prognostic value of LNR in patients with invasive PCN remains unknown. Methods: We used Surveillance, Epidemiology, and End Results (SEER) database to retrieve the baseline characteristics and clinical tumor variables of patients diagnosed with PCN between 1988 and 2014. Survival analyses were performed using the Kaplan-Meier method. Univariate and multivariate analyses were performed to identify factors associated with patient prognosis. Results: A total of 10,656 PCN cases were initially identified. Based on our exclusion criteria, our analyses included data from 1246 cases, of which 479 were patients with lymph node involvement. Patients with high LINT had shorter overall survival (OS) than patients with low LINT (median OS, 13 vs. 21 months; P=0). Our univariate and multivariate analyses identified LNR (P=0) and grade (P=0.010) as independent prognostic factors in patients with invasive PCN. Conclusions: Our findings suggest that LNR is a reliable, independent prognostic factor in patients with invasive PCN, strongly associated with OS and cancer-specific survival (CSS). LNR may represent a promising prognostic factor alternative to the AJCC (the American Joint Committee on Cancer) N stage in patients with node-positive PCN.
引用
收藏
页码:5843 / +
页数:15
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