Impaired endothelium-dependent skin microvascular function during high-dose atorvastatin treatment in patients with type 1 diabetes

被引：22

作者：

Tehrani, Sara ^{[1
]}

Mobarrez, Fariborz ^{[2
]}

Lins, Per-Eric ^{[1
]}

Adamson, Ulf ^{[1
]}

Wallen, Hakan N. ^{[2
]}

Jorneskog, Gun ^{[1
]}

机构：

[1] Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Med, S-18288 Danderyd, Sweden

[2] Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiol, S-18288 Danderyd, Sweden

来源：

DIABETES & VASCULAR DISEASE RESEARCH | 2013年 / 10卷 / 06期

关键词：

Statin; microcirculation; type; 1; diabetes; LASER-DOPPLER FLOWMETRY; MICROANGIOPATHY; HYPERCHOLESTEROLEMIA; MICROPARTICLES; LIPOPROTEINS; DYSFUNCTION; MELLITUS; HUMANS; RISK;

D O I：

10.1177/1479164113491275

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: The present study investigated the effects of lipid-lowering therapy with atorvastatin on skin microvascular function in patients with type 1 diabetes and dyslipidaemia. Methods: Twenty patients received daily treatment with atorvastatin 80 mg or placebo during 2 months in a randomised, double-blind, cross-over study. Forearm skin microcirculation was investigated with laser Doppler perfusion imaging during iontophoresis of acetylcholine and sodium nitroprusside to assess endothelium-dependent and endothelium-independent microvascular reactivity, respectively. Various biochemical markers of endothelial function were also investigated. Results: Endothelium-dependent microvascular reactivity decreased during atorvastatin (p < 0.001), showing a significant treatment effect compared with placebo (p = 0.04). Atorvastatin treatment was also associated with increased haemoglobin A(1C) levels from 7.45% to 7.77% (p = 0.008). Conclusions: The present study shows impaired endothelium-dependent skin microvascular function during high-dose atorvastatin treatment in patients with type 1 diabetes, thus implicating a risk for deterioration of microvascular function during such therapy in these patients.

引用

页码：483 / 488

页数：6

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