The relationship between red blood cell distribution width and myocardial ischemia in dobutamine stress echocardiography

被引:13
作者
Akilli, Hakan [1 ]
Kayrak, Mehmet [1 ]
Aribas, Alpay [1 ]
Alibasic, Hajrudin [1 ]
Yildirim, Oguzhan [1 ]
Sertdemir, Ahmet Lutfi [1 ]
Ozdemir, Kurtulus [1 ]
机构
[1] Necmettin Erbakan Univ, Dept Cardiol, Meram Fac Med, TR-42090 Konya, Turkey
关键词
dobutamine stress echocardiography; ischemia; red blood cell distribution width; CORONARY-ARTERY-DISEASE; LONG-TERM MORTALITY; HEART-FAILURE; ATHEROSCLEROSIS; COUNT; INFLAMMATION; METAANALYSIS; PREDICTION; ANEMIA; RISK;
D O I
10.1097/MCA.0000000000000068
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectivesAlthough elevated red blood cell distribution width (RDW) is associated with adverse outcomes in patients with cardiovascular disease, its role in demonstrating the presence and extent of myocardial ischemia for coronary artery disease is not known. The purpose of this study is to investigate the relationship between RDW and myocardial ischemia by using dobutamine stress echocardiography (DSE).MethodsA total of 917 patients were included in this prospective study. A complete blood analysis was performed for RDW before DSE. According to DSE results, patients were divided into two groups: DSE negative and DSE positive. According to the number of ischemic segments in DSE, patients were divided into three groups: no-ischemic segment, 1-3 ischemic segments, and 4 ischemic segments. In addition, coronary angiography results of DSE-positive groups were assessed in respect of RDW.ResultsThe RDW of the DSE-positive group (n=277) was higher than for the DSE-negative group (n=640) (13.51.5 vs. 12.7 +/- 1.3%, P<0.001, respectively). Elevated RDW values were also related to higher number of ischemic segments (no-ischemic segment group: 12.7 +/- 1.3, 1-3 ischemic segments group: 13.2 +/- 1.5, and 4 ischemic segments group: 14.2 +/- 1.3, P<0.001). A receiver operating curve analysis showed a cut-off value of RDW greater than 13.5% for predicting myocardial ischemia (sensitivity: 57.0%, specificity: 77.8%, positive predictive value: 52.7%, negative predictive value: 80.7%). In addition, positive predictive value of DSE was increased from 82.4 to 94.2% for detecting coronary artery disease by coronary angiography, when RDW (>13.5%) was used.ConclusionRDW is related to the presence and extent of myocardial ischemia in DSE. A high RDW increases the diagnostic accuracy of DSE.
引用
收藏
页码:152 / 158
页数:7
相关论文
共 33 条
  • [1] Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease
    Anderson, Jeffrey L.
    Ronnow, Brianna S.
    Horne, Benjamin D.
    Carlquist, John F.
    May, Heidi T.
    Bair, Tami L.
    Jensen, Kurt R.
    Muhlestein, Joseph B.
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (02) : 169 - 174
  • [2] [Anonymous], 1968, WHO TECH REP SER
  • [3] Importance of RDW value in differential diagnosis of hypochrome anemias
    Aslan, D
    Gümrük, F
    Gürgey, A
    Altay, Ç
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2002, 69 (01) : 31 - 33
  • [4] The use of stress echocardiography for prognostication in coronary artery disease: an overview
    Blagini, E
    Elhendy, A
    Bax, JJ
    Schinkel, AFL
    Poldermans, D
    [J]. CURRENT OPINION IN CARDIOLOGY, 2005, 20 (05) : 386 - 394
  • [5] Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography
    Cavusoglu, Erdal
    Chopra, Vineet
    Gupta, Amit
    Battala, Venkata R.
    Poludasu, Shyam
    Eng, Calvin
    Marmur, Jonathan D.
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2010, 141 (02) : 141 - 146
  • [6] PREDICTION OF CREATININE CLEARANCE FROM SERUM CREATININE
    COCKCROFT, DW
    GAULT, MH
    [J]. NEPHRON, 1976, 16 (01) : 31 - 41
  • [7] Relation Between Red Cell Distribution Width and Clinical Outcomes After Acute Myocardial Infarction
    Dabbah, Saleem
    Hammerman, Haim
    Markiewicz, Walter
    Aronson, Doron
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2010, 105 (03) : 312 - 317
  • [8] ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 Appropriate Use Criteria for Echocardiography
    Douglas, Pamela S.
    Garcia, Mario J.
    Haines, David E.
    Lai, Wyman W.
    Manning, Warren J.
    Patel, Ayan R.
    Picard, Michael H.
    Polk, Donna M.
    Ragosta, Michael
    Ward, R. Parker
    Weiner, Rory B.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (09) : 1126 - 1166
  • [9] Red cell distribution width as a novel prognostic marker in heart failure - Data from the CHARM program and the Duke Databank
    Felker, G. Michael
    Allen, Larry A.
    Pocock, Stuart J.
    Shaw, Linda K.
    McMurray, John J. V.
    Pfeffer, Marc A.
    Swedberg, Karl
    Wang, Duolao
    Yusuf, Salim
    Michelson, Eric L.
    Granger, Christopher B.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (01) : 40 - 47
  • [10] Red cell distribution width in heart failure: Prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state
    Forhecz, Zsolt
    Gombos, Timea
    Borgulya, Gabor
    Pozsonyi, Zoltan
    Prohaszka, Zoltan
    Janoskuti, Livia
    [J]. AMERICAN HEART JOURNAL, 2009, 158 (04) : 659 - 666