Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit

被引：124

作者：

Damljanovic, Ivan ^{[1
]}

Vukicevic, Mirjana ^{[1
]}

Radulovic, Niko ^{[2
]}

Palic, Radosav ^{[2
]}

Ellmerer, Ernst ^{[3
]}

Ratkovic, Zoran ^{[1
]}

Joksovic, Milan D. ^{[1
]}

Vukicevic, Rastko D. ^{[1
]}

机构：

[1] Univ Kragujevac, Fac Sci, Dept Chem, Kragujevac 34000, Serbia

[2] Univ Nis, Fac Sci & Math, Dept Chem, Nish 18000, Serbia

[3] Univ Innsbruck, Inst Organ Chem, A-6020 Innsbruck, Austria

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 04期

关键词：

Vilsmeier-Haack reaction; Ferrocenylpyrazoles; Antimicrobial screening; ANTITUMOR-ACTIVITY; BIOLOGICAL-ACTIVITY; ANTIMALARIAL ACTIVITY; PYRROLNITRIN ANALOGS; IN-VITRO; IDENTIFICATION; NUCLEOSIDES; CHEMISTRY; DESIGN; AGENTS;

D O I：

10.1016/j.bmcl.2009.01.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new imines and amines have been synthesized by condensation of 1H-3-ferrocenyl-1-phenyl-pyrazole-4-carboxaldehyde with the corresponding amines, followed by reduction with sodium borohydride. The synthesized compounds have been screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains, using disc diffusion and broth microdilution susceptibility assays. They have shown a wide range of activities, from completely inactive to the highly active compounds. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1093 / 1096

页数：4

共 45 条

[1] Development of organometallic (organo-transition metal) pharmaceuticals [J].

Allardyce, CS ;

Dorcier, A ;

Scolaro, C ;

Dyson, PJ .

APPLIED ORGANOMETALLIC CHEMISTRY, 2005, 19 (01) :1-10

[2] The effect of 1,3-diaryl-[1H]-pyrazole-4-acetamides on glucose utilization in ob/ob mice [J].

Bebernitz, GR ;

Argentieri, G ;

Battle, B ;

Brennan, C ;

Balkan, B ;

Burkey, BF ;

Eckhardt, M ;

Gao, JP ;

Kapa, P ;

Strohschein, RJ ;

Schuster, HF ;

Wilson, M ;

Xu, DD .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (16) :2601-2611

[3] Design and synthesis of some substituted 1H-pyrazolyl-thiazolo[4,5-d]pyrimidines as anti-inflammatory-antimicrobial agents [J].

Bekhit, AA ;

Fahmy, HTY ;

Rostom, SAF ;

Baraka, AM .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (01) :27-36

[4] Synthesis and antifungal activity of a ferrocene-fluconazole analogue [J].

Biot, C ;

François, N ;

Maciejewski, L ;

Brocard, J ;

Poulain, D .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (08) :839-841

[5] Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue [J].

Biot, C ;

Glorian, G ;

Maciejewski, LA ;

Brocard, JS ;

Domarle, O ;

Blampain, G ;

Millet, P ;

Georges, AJ ;

Abessolo, H ;

Dive, D ;

Lebibi, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (23) :3715-3718

[6]

CECCHI L, 1984, FARMACO-ED SCI, V39, P888

[7]

CECCHI L, 1984, FARMACO-ED SCI, V39, P953

[8] In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine [J].

Domarle, O ;

Blampain, G ;

Agnaniet, H ;

Nzadiyabi, T ;

Lebibi, J ;

Brocard, J ;

Maciejewski, L ;

Biot, C ;

Georges, AJ ;

Millet, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (03) :540-544

[9] ORGANOMETALLIC DERIVATIVES OF PENICILLINS AND CEPHALOSPORINS - NEW CLASS OF SEMISYNTHETIC ANTIBIOTICS [J].

EDWARDS, EI ;

EPTON, R ;

MARR, G .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1975, 85 (02) :C23-C25

[10]

Eid A I, 1978, J Pharm Belg, V33, P303

← 1 2 3 4 5 →