Antibiotics and antibiotic resistance: A bitter fight against evolution

被引：153
作者：
Rodriguez-Rojas, Alexandro [1 ]
Rodriguez-Beltran, Jeronimo [1 ]
Couce, Alejandro [1 ]
Blazquez, Jesus [1 ]
机构：
[1] CSIC, CNB, Canto Blanco 28049, Spain
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2013年 / 303卷 / 6-7期
基金：
欧盟第七框架计划;
关键词：
Antibiotics; Subinhibitory concentration; Mutations; Resistance; Evolution; PROMOTES HORIZONTAL DISSEMINATION; RIBOSOMAL AMBIGUITY MUTATION; STRESS-INDUCED MUTATION; PRODUCTION WASTE-WATER; ESCHERICHIA-COLI; SUBINHIBITORY CONCENTRATIONS; PSEUDOMONAS-AERUGINOSA; PLASMID TRANSFER; STREPTOCOCCUS-PNEUMONIAE; STAPHYLOCOCCUS-AUREUS;
D O I：
10.1016/j.ijmm.2013.02.004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
One of the most terrible consequences of Darwinian evolution is arguably the emergence and spread of antibiotic resistance, which is becoming a serious menace to modern societies. While spontaneous mutation, recombination and horizontal gene transfer are recognized as the main causes of this notorious phenomenon; recent research has raised awareness that sub-lethal concentrations of antibiotics can also foster resistance as an undesirable side-effect. They can produce genetic changes by different ways, including a raise of free radicals within the cell, induction of error-prone DNA-polymerases mediated by SOS response, imbalanced nucleotide metabolism or affect directly DNA. In addition to certain environmental conditions, subinhibitory concentrations of antimicrobials may increase, even more, the mutagenic effect of antibiotics. Here, we review the state of knowledge on antibiotics as promoters of antibiotic resistance. (C) 2013 Elsevier GmbH. All rights reserved.
引用
收藏
页码：293 / 297
页数：5
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