Beyond HPV: Oncomirs as new players in cervical cancer

被引：51

作者：

Reshmi, G. ^{[1
]}

Pillai, M. Radhakrishna ^{[1
]}

机构：

[1] Rajiv Gandhi Ctr Biotechnol, Translat Canc Res Lab, Thiruvananthapuram 695014, Kerala, India

来源：

FEBS LETTERS | 2008年 / 582卷 / 30期

关键词：

MicroRNA; Oncomirs; Cervical cancer; Apoptosis; Tumor suppressor;

D O I：

10.1016/j.febslet.2008.11.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a recently discovered family of 18-24 nucleotide non-coding RNAs that can negatively regulate target mRNAs. All studied multicellular eukaryotes utilize miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. This review discusses the various cancer-relevant miRNAs (oncomirs) especially in cervical tumorigenesis and the potential role of oncomirs as therapeutic agents and targets for the treatment of cervical cancer. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：4113 / 4116

页数：4

共 58 条

[1] Downregulation of microRNAs-143 and-145 in B-cell malignancies [J].

Akao, Yukihiro ;

Nakagawa, Yoshihito ;

Kitade, Yukio ;

Kinoshita, Tomohiro ;

Naoe, Tomoki .

CANCER SCIENCE, 2007, 98 (12) :1914-1920

[2] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[3] Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes [J].

Baskerville, S ;

Bartel, DP .

RNA, 2005, 11 (03) :241-247

[4] Identification of hundreds of conserved and nonconserved human microRNAs [J].

Bentwich, I ;

Avniel, A ;

Karov, Y ;

Aharonov, R ;

Gilad, S ;

Barad, O ;

Barzilai, A ;

Einat, P ;

Einav, U ;

Meiri, E ;

Sharon, E ;

Spector, Y ;

Bentwich, Z .

NATURE GENETICS, 2005, 37 (07) :766-770

[5] Phylogenetic shadowing and computational identification of human microRNA genes [J].

Berezikov, E ;

Guryev, V ;

van de Belt, J ;

Wienholds, E ;

Plasterk, RHA ;

Cuppen, E .

CELL, 2005, 120 (01) :21-24

[6]

Bosch F Xavier, 2003, J Natl Cancer Inst Monogr, P3

[7]

Boyer SN, 1996, CANCER RES, V56, P4620

[8] bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].

Brennecke, J ;

Hipfner, DR ;

Stark, A ;

Russell, RB ;

Cohen, SM .

CELL, 2003, 113 (01) :25-36

[9] Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells [J].

Cai, XZ ;

Lu, SH ;

Zhang, ZH ;

Gonzalez, CM ;

Damania, B ;

Cullen, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (15) :5570-5575

[10] Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance [J].

Calin, GA ;

Croce, CM .

SEMINARS IN ONCOLOGY, 2006, 33 (02) :167-173

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