Synergistic Sc(III)/Au(I)-Catalyzed Dearomative Spiroannulation of 2-(Ethynyl)aryl Cyclopropanes with 2-Aryl Indoles

被引：8

作者：

Xiao, Jun-An ^{[1
]}

Peng, Hai ^{[1
]}

Zhang, Huan ^{[1
]}

Meng, Ru-Fang ^{[1
]}

Lin, Chenxiang ^{[1
]}

Su, Wei ^{[1
]}

Huang, Yanmin ^{[1
]}

机构：

[1] Nanning Normal Univ, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Peoples R China

来源：

ORGANIC LETTERS | 2022年

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC-SYNTHESIS; BRONSTED ACID; RING; CYCLOPENTANNULATION; VINYLCYCLOPROPANES; DERIVATIVES; ALKYLATION;

D O I：

10.1021/acs.orglett.2c03679

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereoselective assembly of spiroindolenines via a synergistic scandium/gold-catalyzed dearomative spiroannulation is herein described. This protocol offers access to a wide variety of spiroindolenine derivatives in 86% average yield with moderate to excellent diastereoselectivities (up to 97:3 dr). The control experimental studies lend support to the bimetallic relay catalysis. Moreover, the scale-up reaction and synthetic transformations of spiroindolenine product further demonstrate its synthetic utility.

引用

页码：8709 / 8713

页数：5

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