Enantioselective MukaiyamaMichael Reaction of Silyl Enol Ethers to 2-Enoylpyridine N-Oxides Catalyzed by Copper- Bis(oxazoline) Complex

被引：15
作者：
George, Jimil [1 ]
Reddy, Basi V. Subba [1 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Hyderabad 500007, Andhra Pradesh, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 2-3期
关键词：
asymmetric catalysis; bis(oxazoline) ligands; copper complexes; Michael reaction; silyl enol ethers; ORGANOCATALYTIC CONJUGATE ADDITION; ASYMMETRIC MICHAEL REACTIONS; HIGHLY EFFICIENT; SILYLKETENE ACETALS; C-C; ALDEHYDES; INDOLES; KETONES;
D O I：
10.1002/adsc.201200631
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A catalytic enantioselective MukaiyamaMichael reaction of 2-enoylpyridine N-oxides has been developed using a simple bis(oxazoline)-copper complex. A variety of silyl enol ethers undergo smooth Michael addition with 2-enoylpyridine N-oxides to furnish the corresponding Michael adducts in high yields with high enantioselectivities (up to 97% ee).
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页码：383 / 388
页数：6
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