Tobacco smoke-induced accelerated cell senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cell senescence is accompanied by the accumulation of damaged cellular components suggesting that in COPD, inhibition of autophagy may contribute to cell senescence. Here we look at whether autophagy contributes to cigarette smoke extract (CSE)-induced cell senescence of primary human bronchial epithelial cells (HBEC), and further evaluate p62 and ubiquitinated protein levels in lung homogenates from COPD patients. We demonstrate that CSE transiently induces activation of autophagy in HBEC, followed by accelerated cell senescence and concomitant accumulation of p62 and ubiquitinated proteins. Autophagy inhibition further enhanced accumulations of p62 and ubiquitinated proteins, resulting in increased senescence and senescence-associated secretory phenotype (SASP) with interleukin (IL)-8 secretion. Conversely, autophagy activation by Torin1, a mammalian target of rapamycin (mTOR inhibitor), suppressed accumulations of p62 and ubiquitinated proteins and inhibits cell senescence. Despite increased baseline activity, autophagy induction in response to CSE was significantly decreased in HBEC from COPD patients. Increased accumulations of p62 and ubiquitinated proteins were detected in lung homogenates from COPD patients. Insufficient autophagic clearance of damaged proteins, including ubiquitinated proteins, is involved in accelerated cell senescence in COPD, suggesting a novel protective role for autophagy in the tobacco smoke-induced senescence-associated lung disease, COPD.
机构:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Brenner, Darren R.
;
McLaughlin, John R.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
Canc Care Ontario, Toronto, ON, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
McLaughlin, John R.
;
Hung, Rayjean J.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Chen, Zhi-Hua
;
Kim, Hong Pyo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Kim, Hong Pyo
;
Sciurba, Frank C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Sciurba, Frank C.
;
Lee, Seon-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Lee, Seon-Jin
;
Feghali-Bostwick, Carol
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Feghali-Bostwick, Carol
;
Stolz, Donna B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Ctr Biol Imag, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Stolz, Donna B.
;
论文数: 引用数:
h-index:
机构:
Dhir, Rajiv
;
Landreneau, Rodney J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Landreneau, Rodney J.
;
Schuchert, Mathew J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Schuchert, Mathew J.
;
Yousem, Samuel A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Yousem, Samuel A.
;
Nakahira, Kiichi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Nakahira, Kiichi
;
Pilewski, Joseph M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Pilewski, Joseph M.
;
Lee, Janet S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Lee, Janet S.
;
Zhang, Yingze
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Zhang, Yingze
;
Ryter, Stefan W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Ryter, Stefan W.
;
Choi, Augustine M. K.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Coppe, Jean -Philippe
;
Desprez, Pierre-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Ruck Inst Age Res, Novato, CA 94945 USA
Calif Pacific Med Ctr, Canc Res Inst, San Francisco, CA 94107 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Desprez, Pierre-Yves
;
Krtolica, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Krtolica, Ana
;
Campisi, Judith
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Ruck Inst Age Res, Novato, CA 94945 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
机构:
Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Hara, Hiromichi
;
Araya, Jun
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Araya, Jun
;
Takasaka, Naoki
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Takasaka, Naoki
;
Fujii, Satoko
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Fujii, Satoko
;
Kojima, Jun
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Kojima, Jun
;
Yumino, Yoko
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Yumino, Yoko
;
Shimizu, Kenichiro
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Shimizu, Kenichiro
;
Ishikawa, Takeo
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Ishikawa, Takeo
;
Numata, Takanori
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Numata, Takanori
;
Kawaishi, Makoto
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Kawaishi, Makoto
;
Saito, Keisuke
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Saito, Keisuke
;
Hirano, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Jikei Univ, Sch Med, Div Chest Dis, Dept Chest Surg, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Hirano, Jun
;
Odaka, Makoto
论文数: 0引用数: 0
h-index: 0
机构:
Jikei Univ, Sch Med, Div Chest Dis, Dept Chest Surg, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Odaka, Makoto
;
Morikawa, Toshiaki
论文数: 0引用数: 0
h-index: 0
机构:
Jikei Univ, Sch Med, Div Chest Dis, Dept Chest Surg, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Morikawa, Toshiaki
;
Hano, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Jikei Univ, Sch Med, Dept Pathol, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Hano, Hiroshi
;
Nakayama, Katsutoshi
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Nakayama, Katsutoshi
;
Kuwano, Kazuyoshi
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
机构:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Brenner, Darren R.
;
McLaughlin, John R.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
Canc Care Ontario, Toronto, ON, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
McLaughlin, John R.
;
Hung, Rayjean J.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, CanadaMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Chen, Zhi-Hua
;
Kim, Hong Pyo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Kim, Hong Pyo
;
Sciurba, Frank C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Sciurba, Frank C.
;
Lee, Seon-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Lee, Seon-Jin
;
Feghali-Bostwick, Carol
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Feghali-Bostwick, Carol
;
Stolz, Donna B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Ctr Biol Imag, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Stolz, Donna B.
;
论文数: 引用数:
h-index:
机构:
Dhir, Rajiv
;
Landreneau, Rodney J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Landreneau, Rodney J.
;
Schuchert, Mathew J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Schuchert, Mathew J.
;
Yousem, Samuel A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Yousem, Samuel A.
;
Nakahira, Kiichi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Nakahira, Kiichi
;
Pilewski, Joseph M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Pilewski, Joseph M.
;
Lee, Janet S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Lee, Janet S.
;
Zhang, Yingze
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Zhang, Yingze
;
Ryter, Stefan W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
Ryter, Stefan W.
;
Choi, Augustine M. K.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Cambridge, MA 02138 USAUniv Pittsburgh, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA 15260 USA
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Coppe, Jean -Philippe
;
Desprez, Pierre-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Ruck Inst Age Res, Novato, CA 94945 USA
Calif Pacific Med Ctr, Canc Res Inst, San Francisco, CA 94107 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Desprez, Pierre-Yves
;
Krtolica, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Krtolica, Ana
;
Campisi, Judith
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Ruck Inst Age Res, Novato, CA 94945 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
机构:
Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Hara, Hiromichi
;
Araya, Jun
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Araya, Jun
;
Takasaka, Naoki
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Takasaka, Naoki
;
Fujii, Satoko
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Fujii, Satoko
;
Kojima, Jun
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Kojima, Jun
;
Yumino, Yoko
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Yumino, Yoko
;
Shimizu, Kenichiro
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Shimizu, Kenichiro
;
Ishikawa, Takeo
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Ishikawa, Takeo
;
Numata, Takanori
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Numata, Takanori
;
Kawaishi, Makoto
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Kawaishi, Makoto
;
Saito, Keisuke
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Saito, Keisuke
;
Hirano, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Jikei Univ, Sch Med, Div Chest Dis, Dept Chest Surg, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Hirano, Jun
;
Odaka, Makoto
论文数: 0引用数: 0
h-index: 0
机构:
Jikei Univ, Sch Med, Div Chest Dis, Dept Chest Surg, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Odaka, Makoto
;
Morikawa, Toshiaki
论文数: 0引用数: 0
h-index: 0
机构:
Jikei Univ, Sch Med, Div Chest Dis, Dept Chest Surg, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Morikawa, Toshiaki
;
Hano, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Jikei Univ, Sch Med, Dept Pathol, Tokyo 1058461, JapanJikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Hano, Hiroshi
;
Nakayama, Katsutoshi
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan
Nakayama, Katsutoshi
;
Kuwano, Kazuyoshi
论文数: 0引用数: 0
h-index: 0
机构:Jikei Univ, Div Resp Dis, Dept Internal Med, Sch Med,Minato Ku, Tokyo 1058461, Japan