Roles of versican in cancer biology - tumorigenesis, progression and metastasis

被引：5

作者：

Du, William Weidong

Yang, Weining

Yee, Albert J.

机构：

[1] Sunnybrook Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada

来源：

HISTOLOGY AND HISTOPATHOLOGY | 2013年 / 28卷 / 06期

关键词：

Tumorigenesis; Metastasis; Invasion; Apoptosis; Versican; EPIDERMAL-GROWTH-FACTOR; CHONDROITIN SULFATE PROTEOGLYCAN; EXTRACELLULAR-MATRIX COMPONENTS; RICH PERICELLULAR MATRIX; BREAST-CANCER; G3; DOMAIN; CELL-PROLIFERATION; P-SELECTIN; G1; CLINICOPATHOLOGICAL FACTORS;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Versican, a large extracellular matrix proteoglycan accumulates in tumor stroma and plays a key role in both malignant transformation and tumor progression. Increased versican expression has been observed in a wide range of malignant tumors, and has been associated with both cancer relapse and poor patient outcomes in breast, prostate, and many other cancer types. Through negatively-charged chondroitin and dermatan sulfate side chains or interactions of the G1 and G3 domains, versican is able to regulate many cellular processes including cell adhesion, proliferation, apoptosis, migration, angiogenesis, invasion and metastasis. In this review, the biological roles that versican plays in cancer development are presented. Therapeutic targeting of versican in malignant tumors is also discussed.

引用

页码：701 / 713

页数：13

共 145 条

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