Nuclear Positioning

被引：372

作者：

Gundersen, Gregg G. ^{[1
]}

Worman, Howard J. ^{[1
,2
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10032 USA

来源：

CELL | 2013年 / 152卷 / 06期

关键词：

CYTOPLASMIC DYNEIN; NEURONAL MIGRATION; MYOSIN-II; LAMIN-A/C; MEMBRANE PROTEIN; CELL-ADHESION; KASH DOMAIN; ACTIN FLOW; TAN LINES; ENVELOPE;

D O I：

10.1016/j.cell.2013.02.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet during cell division, migration, and differentiation, it frequently moves to an asymmetric position aligned with cell function. We consider the toolbox of proteins that move and anchor the nucleus within the cell and how forces generated by the cytoskeleton are coupled to the nucleus to move it. The significance of proper nuclear positioning is underscored by numerous diseases resulting from genetic alterations in the toolbox proteins. Finally, we discuss how nuclear position may influence cellular organization and signaling pathways.

引用

页码：1376 / 1389

页数：14

共 111 条

[1] Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae [J].

Adames, NR ;

Cooper, JA .

JOURNAL OF CELL BIOLOGY, 2000, 149 (04) :863-874

[2] Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis [J].

Attali, Ruben ;

Warwar, Nasim ;

Israel, Ariel ;

Gurt, Irina ;

McNally, Elizabeth ;

Puckelwartz, Megan ;

Glick, Benjamin ;

Nevo, Yoram ;

Ben-Neriah, Ziva ;

Melki, Judith .

HUMAN MOLECULAR GENETICS, 2009, 18 (18) :3462-3469

[3] Bipedal Locomotion in Crawling Cells [J].

Barnhart, Erin L. ;

Allen, Greg M. ;

Juelicher, Frank ;

Theriot, Julie A. .

BIOPHYSICAL JOURNAL, 2010, 98 (06) :933-942

[4] The role of myosin II in glioma invasion of the brain [J].

Beadle, Christopher ;

Assanah, Marcela C. ;

Monzo, Pascale ;

Vallee, Richard ;

Rosenfeld, Steven S. ;

Canoll, Peter .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (08) :3357-3368

[5] IDENTIFICATION OF A NOVEL X-LINKED GENE RESPONSIBLE FOR EMERY-DREIFUSS MUSCULAR-DYSTROPHY [J].

BIONE, S ;

MAESTRINI, E ;

RIVELLA, S ;

MANCINI, M ;

REGIS, S ;

ROMEO, G ;

TONIOLO, D .

NATURE GENETICS, 1994, 8 (04) :323-327

[6] Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy [J].

Bonne, G ;

Di Barletta, MR ;

Varnous, S ;

Bécane, HM ;

Hammouda, EH ;

Merlini, L ;

Muntoni, F ;

Greenberg, CR ;

Gary, F ;

Urtizberea, JA ;

Duboc, D ;

Fardeau, M ;

Toniolo, D ;

Schwartz, K .

NATURE GENETICS, 1999, 21 (03) :285-288

[7] Samp1 is a component of TAN lines and is required for nuclear movement [J].

Borrego-Pinto, Joana ;

Jegou, Thibaud ;

Osorio, Daniel S. ;

Aurade, Frederic ;

Gorjanacz, Matyas ;

Koch, Birgit ;

Mattaj, Iain W. ;

Gomes, Edgar R. .

JOURNAL OF CELL SCIENCE, 2012, 125 (05) :1099-1105

[8] Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies [J].

Broers, JLV ;

Peeters, EAG ;

Kuijpers, HJH ;

Endert, J ;

Bouten, CVC ;

Oomens, CWJ ;

Baaijens, FPT ;

Ramaekers, FCS .

HUMAN MOLECULAR GENETICS, 2004, 13 (21) :2567-2580

[9] Putting a Notch in our understanding of nuclear migration [J].

Buchman, Joshua J. ;

Tsai, Li-Huei .

CELL, 2008, 134 (06) :912-914

[10] The Ras-ERK pathway: Understanding site-specific signaling provides hope of new anti-tumor therapies [J].

Calvo, Fernando ;

Agudo-Ibanez, Lorena ;

Crespo, Piero .

BIOESSAYS, 2010, 32 (05) :412-421

← 1 2 3 4 5 6 7 8 9 10 →